A case of ovarian stimulation for fertility preservation in a patient with Philadelphia chromosome‐positive acute lymphoblastic leukemia after treatment with dasatinib

Tyrosine kinase inhibitors (TKIs) are effective for treating Philadelphia chromosome‐positive acute lymphoblastic leukemia (Ph+ALL). However, the use of TKIs may decrease the number of collected oocytes during fertility preservation procedures. We report the case of a 19‐year‐old patient with Ph+ALL...

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Published inThe journal of obstetrics and gynaecology research Vol. 47; no. 3; pp. 1182 - 1185
Main Authors Ogawa, Tatsuyuki, Ogi, Maki, Hirata, Shuji
Format Journal Article
LanguageEnglish
Published Kyoto, Japan John Wiley & Sons Australia, Ltd 01.03.2021
Wiley Subscription Services, Inc
Subjects
Acute lymphoblastic leukemia
Adult
Dasatinib
Female
Fertility
Fertility Preservation
Hematopoietic Stem Cell Transplantation
Hematopoietic stem cells
Humans
Induction therapy
Leukemia
Lymphatic leukemia
oocyte retrieval
Oocytes
Ovaries
Ovulation Induction
Philadelphia Chromosome
Philadelphia chromosome‐positive acute lymphoblastic leukemia
Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
Preservation
Protein Kinase Inhibitors - adverse effects
Protein-tyrosine kinase
Remission
tyrosine kinase inhibitor
Young Adult
dasatinib
fertility preservation
tyrosine kinase inhibitor
oocyte retrieval
Philadelphia chromosome-positive acute lymphoblastic leukemia
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Summary:Tyrosine kinase inhibitors (TKIs) are effective for treating Philadelphia chromosome‐positive acute lymphoblastic leukemia (Ph+ALL). However, the use of TKIs may decrease the number of collected oocytes during fertility preservation procedures. We report the case of a 19‐year‐old patient with Ph+ALL for whom 21 oocytes were frozen after controlled ovarian stimulation was initiated 2 days after the completion of 28 days of remission induction therapy with dasatinib. After collecting the oocytes, consolidation therapy was initiated immediately, and a hematopoietic stem cell transplant from her younger brother was scheduled. It is believed that a 2‐day withdrawal period is sufficient for fertility preservation or that the effect of dasatinib on the number of oocytes obtained is minimal.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
content type line 23
ObjectType-Report-1
ISSN:1341-8076
1447-0756
1447-0756
DOI:10.1111/jog.14668