Anti-Obesity Effects of Starter Fermented Kimchi on 3T3-L1 Adipocytes

• Published in: Preventive nutrition and food science Vol. 20; no. 4; pp. 298 - 302
• Main Authors: Lee, Kyung-Hee, Song, Jia-Le, Park, Eui-Seong, Ju, Jaehyun, Kim, Hee-Young, Park, Kun-Young
• Format: Journal Article
• Language: English
• Published: Korea (South) 한국식품영양과학회 01.12.2015; The Korean Society of Food Science and Nutrition
• Subjects: Research Note; 식품과학; starters; 3T3-L1 cells; kimchi; antiobesity
• ISSN: 2287-1098; 2287-8602
• DOI: 10.3746/pnf.2015.20.4.298

The anti-obesity effects of starter (Leuconostoc mesenteroides+Lactobacillus plantarum) fermented kimchi on 3T3-L1 adipocyte were studied using naturally fermented kimchi (NK), a functional kimchi (FK, NK supplemented with green tea), and FK supplemented with added starters (FKS). Oil red O staining and cellular levels of triglyceride (TG) and glycerol were used to evaluate the in vitro anti-obesity effects of these kimchis in 3T3-L1 cells. The expressions of adipogenesis/lipogenesis-related genes of peroxisome proliferator-active receptor (PPAR)-γ, CCAAT/enhance-binding protein (C/EBP)-α, and fatty acid synthase (FAS) were determined by RT-PCR. Kimchis, especially FKS, markedly decreased TG levels and increased levels of intracellular glycerol and lipid lipolysis. In addition, FKS also reduced the mRNA levels of PPAR-γ, C/EBP-α, and FAS, which are related to adipogenesis/lipogenesis in 3T3-L1 cells. These results suggest the anti-obesity effects of FKS were to due to enhanced lipolysis and reduced adipogenesis/lipogenesis in 3T3-L1 adipocytes.