Neuropathological findings in primary generalized epilepsy: a study of eight cases

On neuropathological investigation of eight cases with primary generalized epilepsy, none showed elective parenchymal necrosis, which is regarded (qualitatively and topologically) as characteristic of epilepsy in classical neuropathology. In seven of the eight cases, however, marked microdysgenesis...

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Published inEpilepsia (Copenhagen) Vol. 25; no. 1; p. 8
Main Authors Meencke, H J, Janz, D
Format Journal Article
LanguageEnglish
Published United States 01.02.1984
Subjects
Adolescent
Adult
Brain - abnormalities
Brain - pathology
Child
Electroencephalography
Epilepsy - pathology
Epilepsy - physiopathology
Female
Humans
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Summary:On neuropathological investigation of eight cases with primary generalized epilepsy, none showed elective parenchymal necrosis, which is regarded (qualitatively and topologically) as characteristic of epilepsy in classical neuropathology. In seven of the eight cases, however, marked microdysgenesis with varying regional distribution was found. These maturation disturbances are to be interpreted as pathological and refute the currently held view that there is no evidence of pathological brain damage in primary generalized epilepsy.
ISSN:0013-9580
DOI:10.1111/j.1528-1157.1984.tb04149.x