MicroRNA-215-3p Suppresses the Growth, Migration, and Invasion of Colorectal Cancer by Targeting FOXM1

• Published in: Technology in cancer research & treatment Vol. 18; p. 1533033819874776
• Main Authors: Tang, Xiaowei, Shi, Xianfeng, Wang, Nianfei, Peng, Wanren, Cheng, Zhendong
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.01.2019; Sage Publications Ltd
• Subjects: Animals; Cancer; Cell Line, Tumor; Cell Movement - genetics; Cell Proliferation - genetics; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - genetics; Disease Models, Animal; Forkhead Box Protein M1 - genetics; Forkhead protein; Gene Expression; Gene Expression Regulation, Neoplastic; Genes, Reporter; Health risk assessment; Humans; Lymph nodes; Metastases; Metastasis; Mice; MicroRNAs; MicroRNAs - genetics; miRNA; Original; Phenotype; Promoter Regions, Genetic; RNA Interference; Tumor suppressor genes; Tumorigenesis; migration; colorectal cancer; miRNA-215-3p; invasion; FOXM1
• ISSN: 1533-0346; 1533-0338
• DOI: 10.1177/1533033819874776

Previous investigations have indicated that microRNA-215-3p is dysregulated in many kinds of cancers and functions as oncogene or tumor suppressor. However, the potential role of microRNA-215-3p in the progression of colorectal cancer remains not well known. Herein, we demonstrated that microRNA-215-3p was downregulated in human colorectal cancer tissues and was reversely correlated to the lymph node metastasis of colorectal cancer. Overexpression of microRNA-215-3p inhibited the clonogenic abilities and metastasis-relevant traits of colorectal cancer cell in vitro. Consistently, upregulation of microRNA-215-3p inhibited the growth and metastasis of colorectal cancer cell in vivo. Forkhead box protein M1 was identified as a direct target of microRNA-215-3p and reexpression of forkhead box protein M1 reversed the suppressive impacts of microRNA-215-3p on the growth, mobility, and invasion abilities of colorectal cancer cell. Altogether, these results revealed the vital role of microRNA-215-3p in the tumorigenesis and metastasis of colorectal cancer.