Pediatric Extrapolation in Type 2 Diabetes: Future Implications of a Workshop

Extrapolation from adults to youth with type 2 diabetes (T2D) is challenged by differences in disease progression and manifestation. This manuscript presents the results of a mock‐team workshop focused on examining the typical team‐based decision process used to propose a pediatric development plan...

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Published inClinical pharmacology and therapeutics Vol. 108; no. 1; pp. 29 - 39
Main Authors Barrett, Jeffrey S., Bucci‐Rechtweg, Christina, Amy Cheung, S. Y., Gamalo‐Siebers, Margaret, Haertter, Sebastian, Karres, Janina, Marquard, Jan, Mulugeta, Yeruk, Ollivier, Cecile, Strougo, Ashley, Yanoff, Lisa, Yao, Lynne, Zeitler, Philip
Format Journal Article
LanguageEnglish
Published United States 01.07.2020
Subjects
Adolescent
Adult
Age Factors
Diabetes Mellitus, Type 2 - drug therapy
Diabetes Mellitus, Type 2 - epidemiology
Diabetes Mellitus, Type 2 - physiopathology
Disease Progression
Education - methods
Humans
Hypoglycemic Agents - pharmacology
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Summary:Extrapolation from adults to youth with type 2 diabetes (T2D) is challenged by differences in disease progression and manifestation. This manuscript presents the results of a mock‐team workshop focused on examining the typical team‐based decision process used to propose a pediatric development plan for T2D addressing the viability of extrapolation. The workshop was held at the American Society for Clinical Pharmacology and Therapeutics (ASCPT) in Orlando, Florida on March 21, 2018.
ISSN:0009-9236
1532-6535
DOI:10.1002/cpt.1805