Commensal Bacteria-Dependent CD8αβ + T Cells in the Intestinal Epithelium Produce Antimicrobial Peptides
The epithelium of the intestine functions as the primary "frontline" physical barrier for protection from enteric microbiota. Intraepithelial lymphocytes (IELs) distributed along the intestinal epithelium are predominantly CD8 T cells, among which CD8αβ IELs are a large population. In this...
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Published in | Frontiers in immunology Vol. 9; p. 1065 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
16.05.2018
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Subjects | |
Online Access | Get full text |
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Summary: | The epithelium of the intestine functions as the primary "frontline" physical barrier for protection from enteric microbiota. Intraepithelial lymphocytes (IELs) distributed along the intestinal epithelium are predominantly CD8
T cells, among which CD8αβ
IELs are a large population. In this investigation, the proportion and absolute number of CD8αβ
IELs decreased significantly in antibiotic-treated and germ-free mice. Moreover, the number of CD8αβ
IELs was correlated closely with the load of commensal microbes, and induced by specific members of commensal bacteria. Microarray analysis revealed that CD8αβ
IELs expressed a series of genes encoding potent antimicrobial peptides (AMPs), whereas CD8αβ
splenocytes did not. The antimicrobial activity of CD8αβ
IELs was confirmed by an antimicrobial-activity assay. In conclusion, microbicidal CD8αβ
IELs are regulated by commensal bacteria which, in turn, secrete AMPs that have a vital role in maintaining the homeostasis of the small intestine. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Specialty section: This article was submitted to Mucosal Immunity, a section of the journal Frontiers in Immunology Edited by: Javier Ochoa-Reparaz, Eastern Washington University, United States Reviewed by: Janneke N. Samsom, Erasmus University Rotterdam, Netherlands; Paul King, Monash University, Australia |
ISSN: | 1664-3224 1664-3224 |
DOI: | 10.3389/fimmu.2018.01065 |