Gynura procumbens Extract Alleviates Postprandial Hyperglycemia in Diabetic Mice

• Published in: Preventive nutrition and food science Vol. 21; no. 3; pp. 181 - 186
• Main Authors: Choi, Sung-In, Park, Mi Hwa, Han, Ji-Sook
• Format: Journal Article
• Language: English
• Published: Korea (South) 한국식품영양과학회 01.09.2016; The Korean Society of Food Science and Nutrition
• Subjects: 식품과학; postprandial hyperglycemia; α-glucosidase; α-amylase; Gynura procumbens extract
• ISSN: 2287-1098; 2287-8602
• DOI: 10.3746/pnf.2016.21.3.181

This study was designed to investigate the inhibitory effect of extract against carbohydrate digesting enzymes and its ability to ameliorate postprandial hyperglycemia in streptozotocin (STZ)-induced diabetic mice. extract showed prominent α-glucosidase and α-amylase inhibitory effects. The half-maximal inhibitory concentration (IC ) of extract against α-glucosidase and α-amylase was 0.092±0.018 and 0.084±0.027 mg/mL, respectively, suggesting that the α-amylase inhibition activity of the extract was more effective than that of the positive control, acarbose (IC =0.164 mg/mL). The increase in postprandial blood glucose levels was more significantly alleviated in the extract group than in the control group of STZ-induced diabetic mice. Moreover, the area under the curve significantly decreased with extract administration in STZ-induced diabetic mice. These results suggest that extract may help alleviate postprandial hyperglycemia by inhibiting carbohydrate digesting enzymes.