Histological severity of maternal and fetal inflammation is correlated with the prevalence of maternal clinical signs

• Published in: The journal of obstetrics and gynaecology research Vol. 48; no. 6; pp. 1318 - 1327
• Main Authors: Maki, Yohei, Sato, Yuichiro, Furukawa, Seishi, Sameshima, Hiroshi
• Format: Journal Article
• Language: English
• Published: Kyoto, Japan John Wiley & Sons Australia, Ltd 01.06.2022; Wiley Subscription Services, Inc
• Subjects: Birth weight; Chorioamnionitis; C‐reactive protein; Fetuses; Inflammation; Patients; placenta; premature birth; preterm premature rupture of membranes; Umbilical cord; preterm premature rupture of membranes; placenta; C-reactive protein; premature birth; chorioamnionitis
• ISSN: 1341-8076; 1447-0756
• DOI: 10.1111/jog.15241

Aim To evaluate whether there is a stepwise increase in the prevalence of maternal clinical signs according to the severity of histological inflammation in the chorioamniotic membranes, placenta, and umbilical cord in preterm deliveries. Methods This retrospective study, conducted between January 2007 and May 2017, included patients with preterm delivery between 22 and 33 weeks. The histological findings of maternal/fetal inflammatory responses were staged and graded according to the Amsterdam Placental Workshop Group consensus statement. Correlations between the histological severity of maternal/fetal inflammatory responses and the prevalence of clinical chorioamnionitis and clinical signs were evaluated using the Cochran–Armitage trend test. Results A total of 138 patients were included. The stage and grade of the maternal inflammatory response were correlated with earlier gestational weeks at delivery and lighter birth weight. The prevalence of clinical chorioamnionitis was significantly correlated with a higher stage and grade of the maternal inflammatory response (Gibbs/Lencki criteria: 15.8%/15.8% in Stage 3, 16.3%/14% in Grade 2). No significant correlations were observed between gestational weeks at delivery and birth weight and stage/grade of fetal inflammatory response. The prevalence of clinical chorioamnionitis was significantly correlated with higher stage and grade of fetal inflammatory response (Gibbs/Lencki criteria: 25%/25% in Stage 3 and 29.4%/29.4% in Grade 2). Conclusion Correlations exist between the severity of histological maternal/fetal inflammatory responses and the prevalence of clinical chorioamnionitis and positive maternal clinical signs in preterm deliveries. However, the prevalence of clinical chorioamnionitis was 20%–30% even in the most severe fetal inflammatory responses.