Influence of cerebral white matter hyperintensities on cognitive impairment in elderly medical patients
Aim We investigated the characteristics of elderly medical patients with white matter hyperintensities on magnetic resonance imaging. Methods A total of 213 patients (123 men and 90 women; mean age 74.8 years) reported their history of hypertension, diabetes, dyslipidemia, previous stroke, coronary...
Saved in:
Published in | Geriatrics & gerontology international Vol. 17; no. 10; pp. 1488 - 1493 |
---|---|
Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Japan
Blackwell Publishing Ltd
01.10.2017
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Aim
We investigated the characteristics of elderly medical patients with white matter hyperintensities on magnetic resonance imaging.
Methods
A total of 213 patients (123 men and 90 women; mean age 74.8 years) reported their history of hypertension, diabetes, dyslipidemia, previous stroke, coronary heart disease and chronic kidney disease (CKD). All patients completed the Mini‐Mental State Examination and Geriatric Depression Scale. White matter hyperintensities were evaluated for the periventricular region, basal ganglia (BGH), deep white matter and infratentorial region, and brain atrophy was calculated as bicaudate ratios.
Results
Patients with cognitive impairment (Mini‐Mental State Examination score < 24) were significantly older (P = 0.001), had periventricular region hyperintensities (P = 0.029) and BGH (P = 0.0015), and showed atrophy (P < 0.0001). Logistic regression showed that cognitive impairment was predicted by stroke (OR 2.5, 95% CI 0.033–0.894, P = 0.036) and atrophy (OR 8.43, 95% CI 5.71–37.0, P = 0.0109). Multiple regressions showed that BGH was associated with CKD (β = 0.213; P = 0.003), and infratentorial region was associated with stroke (β = 0.157; P =0.035) and CKD (β = 0.172; P = 0.016). Periventricular region was associated with age (β = 0.2; P = 0.011) and Geriatric Depression Scale (β = 0.151; P = 0.037), and deep white matter hyperintensities with age (β = 0.189; P = 0.016).
Conclusions
Although cognitive impairment in elderly medical patients is associated with stroke and brain atrophy, white matter hyperintensities, especially BGH and infratentorial region, are associated with cognitive decline in relation to CKD. Geriatr Gerontol Int 2017; 17: 1488–1493. |
---|---|
Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1444-1586 1447-0594 |
DOI: | 10.1111/ggi.12900 |