Sweriyunnanlactone A, one unusual secoiridoid trimer from Swertia yunnanensis

[Display omitted] One unusual secoiridoid trimer, namely sweriyunnanlactone A (1), was isolated from Swertia yunnanensis under the guidance of LC–MS analysis. Sweriyunnanlactone A with a phenyl ring (ring F) was the first example of secoiridoid trimer featuring a C28 skeleton. Its structure was dete...

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Published inTetrahedron letters Vol. 56; no. 17; pp. 2163 - 2166
Main Authors Geng, Chang-An, Chen, Xing-Long, Huang, Xiao-Yan, Ma, Yun-Bao, He, Kang, Zhou, Ning-Jia, Cao, Tuan-Wu, Zhang, Xue-Mei, Chen, Ji-Jun
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 22.04.2015
Elsevier
Subjects
Anti-HBV activity
Chemistry
Chemistry, Organic
LC–MS guided isolation
Physical Sciences
Science & Technology
Secoiridoid trimer
Sweriyunnanlactone A
Swertia yunnanensis
Sweriyunnanlactone A
Anti-HBV activity
LC–MS guided isolation
Swertia yunnanensis
Secoiridoid trimer
CHEMICAL-CONSTITUENTS
LACTONES
LC-MS guided isolation
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Summary:[Display omitted] One unusual secoiridoid trimer, namely sweriyunnanlactone A (1), was isolated from Swertia yunnanensis under the guidance of LC–MS analysis. Sweriyunnanlactone A with a phenyl ring (ring F) was the first example of secoiridoid trimer featuring a C28 skeleton. Its structure was determined by extensive HRESIMS, 1D and 2D NMR spectroscopic data, and GIAO 13C NMR calculation. Compound 1 showed weak inhibition on HBV DNA replication with an IC50 value of 60.76μM (SI=12.6) on HepG 2.2.15 cell line in vitro.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2015.03.057