Hempseed water extract ameliorates atherosclerosis in apolipoprotein E knockout mice

• Published in: Food science and biotechnology Vol. 21; no. 4; pp. 927 - 932
• Main Authors: Seo, J.H., Konkuk University, Seoul, Republic of Korea, Jeong, E.S., Konkuk University, Seoul, Republic of Korea, Lee, K.S., Konkuk University, Seoul, Republic of Korea, Heo, S.H., Konkuk University, Seoul, Republic of Korea, Jeong, D.G., Konkuk University, Seoul, Republic of Korea, Lee, S.J., Korea University, Seoul, Republic of Korea, Kim, E.S., Konkuk University, Seoul, Republic of Korea, Choi, Y.K., Konkuk University, Seoul, Republic of Korea
• Format: Journal Article
• Language: English
• Published: Heidelberg The Korean Society of Food Science and Technology 01.08.2012; 한국식품과학회
• Subjects: Aorta; Apolipoprotein E; apolipoprotein E knockout mice; ARTERIOSCLEROSE; ARTERIOSCLEROSIS; Chemistry; Chemistry and Materials Science; Cholesterol; Food Science; Heart; hempseed; Inoculation; low-density lipoprotein; Nutrition; Plaques; Research Article; Risk factors; Sinus; 식품과학; atherosclerosis; apolipoprotein E knockout mice; hempseed; low-density lipoprotein
• ISSN: 1226-7708; 2092-6456
• DOI: 10.1007/s10068-012-0122-1

The principal objective of this experiment was to evaluate the anti-atherosclerotic activity of hempseed water extract in apolipoprotein E knockout (ApoE KO) mice. Fourteen male ApoE KO mice were divided into 2 groups and were treated via intragastric inoculation for 14 weeks. The hempseed water extract (HWE) inoculation group exhibited greater gains in weight as compared to the control group, which was inoculated with distilled water. Plaque lesion areas in the aortic sinus were reduced in the HWE group. Total plasma cholesterol, LDL-cholesterol, atherosclerotic index, and cardiac risk factor were all reduced in the HWE group. These results demonstrate that HWE is an excellent nutritional resource and evidences anti-atherosclerotic activity in ApoE KO mice. Further studies will be required to assess the pharmacological mechanisms underlying these effects.