Modeling, Simulation, and Experimental Evaluation of Continuous Chromatographic Separation of Ketamine Enantiomers on MCTA

• Published in: Journal of liquid chromatography & related technologies Vol. 31; no. 20; pp. 3057 - 3076
• Main Authors: Barreto, Amaro Gomes, Silva, Ivanildo José da, dos Santos, Marco Antônio Garcia, Veredas, Vinicius de, Santana, Cesar Costapinto
• Format: Journal Article
• Language: English
• Published: Colchester Taylor & Francis Group 03.11.2008; Taylor & Francis
• Subjects: Analysis; Biological and medical sciences; Chiral separation; Equilibrium theory; General pharmacology; Ketamine; Liquid chromatography; Medical sciences; Pharmacology. Drug treatments; Simulated moving bed; Simulated moving bed; Separation; Psychotropic; Preparative chromatography; Theoretical study; Liquid chromatography; Experimental study; Modeling; Aminoketone; Ketamine; General anesthetic; Optical resolution; Enantiomer; Hallucinogen; Chiral separation; Equilibrium theory; Drug of abuse; Mathematical model
• ISSN: 1082-6076; 1520-572X
• DOI: 10.1080/10236660802479507

Results on the chiral separation of ketamine enantiomers by simulated moving bed (SMB) chromatography using microcrystalline cellulose triacetate (MCTA) columns are reported. Experimental data obtained with the SMB laboratory unit showed purities above 99.5% in the raffinate stream and above 97.7% in the extract stream. A simulation approach based on true moving bed (TMB) was applied to validate the performance of the SMB in steady state regime, taking into account the non-linear isotherms, non-ideal effects, and the non-homogeneities of the eight columns. The experimental and calculated results are in agreement with the internal profiles calculated by the TMB approach.