Effects of recombinant human growth hormone on remnant liver after hepatectomy in hepatocellular carcinoma with cirrhosis

• Published in: World journal of gastroenterology : WJG Vol. 10; no. 9; pp. 1292 - 1296
• Main Authors: Luo, Shi-Min, Liang, Li-Jian, Lai, Jia-Ming
• Format: Journal Article
• Language: English
• Published: United States Department of Hepatobiliary Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China 01.05.2004; Baishideng Publishing Group Inc
• Subjects: Adult; Aged; Albumins - metabolism; Blood Glucose - metabolism; Carcinoma, Hepatocellular - surgery; Female; Hepatectomy; Human Growth Hormone - pharmacology; Humans; Ki-67 Antigen - metabolism; Liver - chemistry; Liver - drug effects; Liver - metabolism; Liver Cancer; Liver Neoplasms - surgery; Liver Regeneration - physiology; Male; Middle Aged; Parenteral Nutrition; Recombinant Proteins - pharmacology; Transferrin - metabolism; 免疫组织化学; 肝切除术; 肝硬化; 肝细胞癌; 重组人生长激素
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v10.i9.1292

AIM:To explore the dffects of recombinant human growth hormone(rhGH) on the remnant liver after hepatectomy in hepatocellular carcinoma with liver cirrhosis.METHODS:Twenty-four patients with hepoatocellular carcinoma who underwent hepatectomy were randomly diveded into 2 groups:parenteral nutrition(PN) group (n=12) and rhGH+PN group (n=12).Liver function,blood glucose,AFP,serum prealbumin and transferrin were detected before operation,at post-operative d 1 and d 6.Albumin (ALB) mRNA in liver biopsy specimens was detected by RT-PCR at post-operative d 6.Liver Ki67 immunohistochemical staining was studied.RESULTS:On post-operative d 6,compared with PN grouop,the levels of blood glucose,serum prealbumin,transferrin,the expression of hepoatic ALB mRNA and liver Ki67 labeling index were higher in rhGH+PN group.CONCLUSION:rhGH can improve protein synthesis and liver regeneration after hipatectomy in hepatocellular carcinoma with liver cirrhosis.