Risk factors for subchondral insufficiency fracture of the femoral head in renal transplant patients

• Published in: Journal of bone and mineral metabolism Vol. 40; no. 6; pp. 968 - 973
• Main Authors: Higuchi, Yoshitoshi, Tomosugi, Toshihide, Futamura, Kenta, Okada, Manabu, Kusano, Taiki, Sawada, Hideyoshi, Kobayashi, Kazuyoshi, Narumi, Shunji, Watarai, Yoshihiko, Goto, Norihiko, Ando, Toshihiro, Sato, Koji
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 01.11.2022; Springer Nature B.V
• Subjects: Antigens; Bone mineral density; Femur; Fractures; Graft rejection; Immunosuppressive agents; Kidney transplantation; Magnetic resonance imaging; Medicine; Medicine & Public Health; Metabolic Diseases; Original Article; Orthopedics; Osteoporosis; Parathyroid hormone; Patients; Phosphorus; Risk factors; Steroid hormones; Transplants & implants; Renal transplant; Femoral head; Subchondral insufficiency fracture; MRI; Risk factor
• ISSN: 0914-8779; 1435-5604
• DOI: 10.1007/s00774-022-01360-4

Introduction Risk factors associated with subchondral insufficiency fracture (SIF) of the femoral head have not been established. The aim of the present study was to determine the incidence and risk factors for SIF of the femoral head following renal transplantation (RT). Materials and methods We analyzed the cases of 681 RT patients (mean age at surgery: 49.5 ± 13.6 years, 249 women, 432 men) to determine the incidence of SIF. Hip magnetic resonance imaging (MRI) was performed 6 months post-RT. The following potential predictors of SIF were evaluated: (1) patient’s condition at RT: bone mineral density (BMD), pre-RT laboratory values including calcium (Ca), phosphorus (P), calcium-phosphorus product (Ca × P), and intact parathyroid hormone; the patient and donor’s blood relationship; and mismatching number of human leukocyte antigens (HLAs), and (2) post-RT dosage(s) of steroid(s), the immunosuppressive regimen, and the incidence of acute rejection. Results SIF was observed in 15 hips (13 patients, 1.9%). We successfully matched 39 patients without SIF. A multivariate logistic regression analysis adjusted for cumulative dosages of steroids, revealed the following were risk factors for SIF: osteoporosis (OR: 11.4, p  = 0.046), lumbar BMD (OR: 0.003, p  = 0.038), pre-RT serum P (OR 2.68, p  = 0.004), and pre-RT serum Ca × P (OR: 1.11, p  = 0.005). Conclusion Since osteoporosis, the lumbar BMD, serum P, and serum Ca × P were identified as risk factors for a post-RT SIF, these factors should be evaluated before RT for the prediction of the SIF risk.