A flexible synthesis of novel homoharringtonine ester chain

[Display omitted] New homoharringtonine ester chains bearing aryl substituents were obtained using a flexible synthesis. d-Malic acid was utilized to achieve the diastereoselective allylation at the C2′ center. A key oxidative Mizoroki–Heck reaction allowed the coupling of various phenyl boronic aci...

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Bibliographic Details
Published inTetrahedron letters Vol. 57; no. 2; pp. 216 - 218
Main Authors Nguyen, Thi Hong Nhung, Bui, Thai Thanh Thu, Pham, Phong Van, Mac, Dinh Hung
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 13.01.2016
Elsevier
Subjects
Boronic acids
Chemistry
Chemistry, Organic
d-Malic acid
Homoharringtonine
Mizoroki–Heck reaction
Physical Sciences
Science & Technology
Homoharringtonine
Mizoroki–Heck reaction
Boronic acids
d-Malic acid
Mizoroki-Heck reaction
D-Malic acid
HECK TYPE REACTION
BOND
ALKALOIDS
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Summary:[Display omitted] New homoharringtonine ester chains bearing aryl substituents were obtained using a flexible synthesis. d-Malic acid was utilized to achieve the diastereoselective allylation at the C2′ center. A key oxidative Mizoroki–Heck reaction allowed the coupling of various phenyl boronic acids with the allyl intermediate to provide arylated products in excellent yields.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2015.12.012