Diverse gatekeepers for mesoporous silica nanoparticle based drug delivery systems
Conventional cancer chemotherapy is often associated with toxicity issues. Thus, new drug delivery systems (DDSs) are developed as alternatives owing to their potential to selectively target affected cells while sparing normal tissues. Among them, noninvasive and biocompatible mesoporous silica nano...
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| Published in | Chemical Society reviews Vol. 46; no. 19; pp. 624 - 645 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
02.10.2017
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Conventional cancer chemotherapy is often associated with toxicity issues. Thus, new drug delivery systems (DDSs) are developed as alternatives owing to their potential to selectively target affected cells while sparing normal tissues. Among them, noninvasive and biocompatible mesoporous silica nanoparticle (MSN)-based targeted DDSs have developed rapidly. In particular, controlled gatekeepers capping the pore entrances of MSNs play prominent and crucial roles in achieving specific drug release and avoiding premature leakage in the delivery process before the target is reached, and perfect gatekeepers can only be removed under specific internal or external stimuli, such as pH, redox potential, temperature, biomolecules, light, magnetic field and ultrasound, or a combination of these stimuli, which is significant for precise therapeutic treatments and potential applications in human bodies. Thus, the main focus of this review is to highlight the most recent progress on the design of various controlled MSN gatekeepers to achieve 'zero premature release' drug delivery. The diverse gatekeepers are categorised into the following kinds according to their types and characteristics: (1) polymers; (2) inorganic nanomaterials; (3) host-guest assemblies; and (4) biomacromolecules. This review will offer a broad palette of opportunities for researchers with interests including nanomaterial fabrication and modification, targeted drug delivery and stimuli-responsive drug release.
Progress on the design of diverse gatekeepers for mesoporous silica nanoparticle based drug delivery systems is summarized. |
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| Bibliography: | Jia Wen received her BS from the Innovation Experimental College, Northwest A&F University. She is pursuing her PhD degree under the guidance of Prof. Shiguo Sun at the College of Chemistry & Pharmacy, Northwest A&F University. Her research interest is mainly focused on the fabrication and modification of carbon/silicon based nanomaterials and their applications for drug delivery and bioimaging. Hongjuan Li, an associate professor at the College of Chemistry & Pharmacy, Northwest A&F University, obtained her PhD in 2010 for her work on the development of functional nanocomposites. Her current interest is focused on the development of electrochemical and fluorescent biosensors based on layered double hydroxides. Shiguo Sun, a professor and doctoral supervisor at the College of Chemistry & Pharmacy, Northwest A&F University, obtained his PhD degree in 2003 from Dalian University of Technology. His research interests include functional molecules with special optical and electrochemical properties, self-assembly chemistry of carbon nanotubes/graphene materials for DNA and protein sensing, drug delivery and fluorescence tracing, and electrochemiluminescence and luminescence sensors. Yongqian Xu, a professor and doctoral supervisor at the College of Chemistry & Pharmacy, Northwest A&F University, obtained his PhD in Applied Chemistry in 2006 from Dalian University of Technology. His current interests focus on the design and synthesis of colorimetric and fluorescence based sensors, nanosensors, and functional materials. Kui Yang obtained his BS degree from the Innovation Experimental College, Northwest A&F University. He is pursuing his PhD degree under the supervision of Prof. Zhichao Pei at the College of Chemistry & Pharmacy, Northwest A&F University. His research interests include the synthesis and assembly of pillararenes, molecular recognition, host-guest chemistry and drug delivery. Fengyu Liu, an associate professor at the State Key Laboratory of Fine Chemicals, School of Chemistry, Dalian University of Technology, obtained her PhD degree in 2006 from Dalian University of Technology. Her research interests include functional molecules with special optical and electrochemical properties, electrochemiluminescence and luminescence sensors. |
| ISSN: | 0306-0012 1460-4744 |
| DOI: | 10.1039/c7cs00219j |