Antitoxic Immunity to Cholera in Isolated Perfused Canine Ileal Segments

A technique of challenging isolated perfused canine ileum with cholera enterotoxin is described. By this technique it was not possible to demonstrate that antitoxic immunity was an integral part of the small bowel of immunized animals. Perfusion of the study segments with blood containing antitoxin...

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Bibliographic Details
Published inThe Journal of infectious diseases Vol. 121; no. Supplement; pp. S132 - S136
Main Authors CurIin, George T., Carpenter, Charles C. J.
Format Journal Article
LanguageEnglish
Published United States The University of Chicago Press 01.05.1970
University of Chicago Press
Subjects
Animals
Antibodies
Antibody Formation
Antitoxins
Canines
Cholera
Cholera - immunology
Control loops
Dogs
Electrolytes
Enterotoxins
Ileum - immunology
Immunity
Methods
Perfusion
Session IV: Immunologic Mechanisms in the Gastrointestinal Tract
Small intestine
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Summary:A technique of challenging isolated perfused canine ileum with cholera enterotoxin is described. By this technique it was not possible to demonstrate that antitoxic immunity was an integral part of the small bowel of immunized animals. Perfusion of the study segments with blood containing antitoxin did, however, prevent any detectable response to challenge with enterotoxin. These observations support the view that the antibodies effective in neutralizing cholera enterotoxin are primarily derived from the circulating blood and not from the wall of the small bowel.
Bibliography:ark:/67375/HXZ-V7VS6DS3-2
This work was supported by research grant AI-07625 from the National Institutes of Health, under the auspices of the United States-Japan Cooperative Medical Science Program, and by a grant from the World Health Organization.
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ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/121.Supplement.S132