Optimization using a Factorial Design for the Separation of Trandolapril and Verapamil by Capillary Electrophoresis
A capillary zone electrophoresis method is developed to achieve the separation and determination of two cardiac drugs, trandolapril and verapamil. Optimisation of the method is based on the use of a factorial design, which is applied in order to obtain more information in the factorial space and to...
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Published in | Journal of liquid chromatography & related technologies Vol. 30; no. 20; pp. 2975 - 2988 |
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Main Authors | , , , , , |
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Language | English |
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Taylor & Francis Group
01.10.2007
Taylor & Francis |
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Abstract | A capillary zone electrophoresis method is developed to achieve the separation and determination of two cardiac drugs, trandolapril and verapamil. Optimisation of the method is based on the use of a factorial design, which is applied in order to obtain more information in the factorial space and to minimise the number of experiments needed to obtain the optimum values for the pH and concentration of electrolyte buffer, the voltage applied and the effects of certain modifiers. Following these studies, the conditions selected for use were running buffer of 10 mM phosphate at pH 7.0, and a voltage of 15 kV. Under these conditions, calibration curves were constructed with good linearity (R>0.999) and suitable LODs. The intra- and inter-day repeatabilities were also evaluated with RSD below 4% for trandolapril and verapamil. The proposed method was applied to the determination of verapamil and trandolapril in pharmaceutical formulations and the recoveries obtained were in agreement with the stated contents for all preparations tested. |
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AbstractList | A capillary zone electrophoresis method is developed to achieve the separation and determination of two cardiac drugs, trandolapril and verapamil. Optimisation of the method is based on the use of a factorial design, which is applied in order to obtain more information in the factorial space and to minimise the number of experiments needed to obtain the optimum values for the pH and concentration of electrolyte buffer, the voltage applied and the effects of certain modifiers. Following these studies, the conditions selected for use were running buffer of 10 mM phosphate at pH 7.0, and a voltage of 15 kV. Under these conditions, calibration curves were constructed with good linearity (R>0.999) and suitable LODs. The intra- and inter-day repeatabilities were also evaluated with RSD below 4% for trandolapril and verapamil. The proposed method was applied to the determination of verapamil and trandolapril in pharmaceutical formulations and the recoveries obtained were in agreement with the stated contents for all preparations tested. |
Author | Àlvarez-Rodríguez, Lluís Bose, Devasish Font-Rubert, Manolo Durgbanshi, Abhilasha Capella-Peiró, María-Elisa Esteve-Romero, Josep |
Author_xml | – sequence: 1 givenname: María-Elisa surname: Capella-Peiró fullname: Capella-Peiró, María-Elisa organization: Àrea de Química Analítica, Q.F.A. , Universitat Jaume I – sequence: 2 givenname: Manolo surname: Font-Rubert fullname: Font-Rubert, Manolo organization: Àrea de Química Analítica, Q.F.A. , Universitat Jaume I – sequence: 3 givenname: Lluís surname: Àlvarez-Rodríguez fullname: Àlvarez-Rodríguez, Lluís organization: Àrea de Química Analítica, Q.F.A. , Universitat Jaume I – sequence: 4 givenname: Josep surname: Esteve-Romero fullname: Esteve-Romero, Josep email: E-mail: josep.esteve@qfs.uji.es organization: Àrea de Química Analítica, Q.F.A. , Universitat Jaume I – sequence: 5 givenname: Abhilasha surname: Durgbanshi fullname: Durgbanshi, Abhilasha organization: Department of Criminology and Forensic Sciences , Dr. H.S. Gour University – sequence: 6 givenname: Devasish surname: Bose fullname: Bose, Devasish organization: Department of Criminology and Forensic Sciences , Dr. H.S. Gour University |
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Keywords | Chemical analysis Peptides Nitrogen heterocycle Calcium antagonist Trandolapril Optimization Peptidyl-dipeptidase A Aralkylamine Bicyclic compound Tablet Quantitative analysis Enzyme Capillary electrophoresis Enzyme inhibitor Oral form Antiarrhythmic agent Cardiac drugs Peptidases Ultraviolet detector Experimental design Dipeptides Dosage form Hydrolases Peptidyl-dipeptidases Verapamil Hard capsule Factorial design ACE inhibitor Chemometrics |
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Snippet | A capillary zone electrophoresis method is developed to achieve the separation and determination of two cardiac drugs, trandolapril and verapamil. Optimisation... |
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SubjectTerms | Analysis Biological and medical sciences Capillary electrophoresis Cardiac drugs Factorial design General pharmacology Medical sciences Pharmacology. Drug treatments Trandolapril Verapamil |
Title | Optimization using a Factorial Design for the Separation of Trandolapril and Verapamil by Capillary Electrophoresis |
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