Direct enantioselective amination of α-ketoester catalyzed by tertiary amine thiourea: a new approach to chiral α-hydroxy-β-amino acid

• Published in: Tetrahedron letters Vol. 56; no. 28; pp. 4220 - 4223
• Main Authors: Fu, Ji-Ya, Wang, Qi-Lin, Gui, Yong-Yuan, Wang, Li-Xin
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 08.07.2015; Elsevier
• Subjects: Chemistry; Chemistry, Organic; Chiral tertiary amine thioureas; Enantioselective amination; Ketoesters; Physical Sciences; Science & Technology; α-Hydroxy-β-amino acids; Ketoesters; α-Hydroxy-β-amino acids; Chiral tertiary amine thioureas; Enantioselective amination; alpha-Flydroxy-beta-amino acids; DEGRADATION; BINDING; CIAP1
• ISSN: 0040-4039; 1873-3581
• DOI: 10.1016/j.tetlet.2015.05.061

A highly enantioselective amination of α-ketoesters catalyzed by chiral tertiary amine thioureas was reported to afford α-hydroxy-β-amino acids with two continuous stereocenters in high yields and enantioselectivities. [Display omitted] A highly enantioselective amination of α-ketoesters catalyzed by chiral tertiary amine thioureas was reported to afford α-hydroxy-β-amino acids with two continuous stereocenters in high yields (up to 90%) and enantioselectivities (up to 93%ee).