Neural substrates of the performance of an auditory verbal memory: between-subjects analysis by fMRI

We studied the neural correlates for the performance of auditory verbal memory using fMRI in 28 normal right-handed volunteers who had to encode and retrieve 50 related word-pair associates. Since the effectiveness of encoding and retrieval processes contribute to memory performance, we combined the...

Full description

Saved in:
Bibliographic Details
Published inBrain research bulletin Vol. 64; no. 2; pp. 115 - 126
Main Authors Ino, Tadashi, Doi, Toshihiko, Kimura, Toru, Ito, Jin, Fukuyama, Hidenao
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 30.08.2004
Subjects
Adult
Auditory Perception - physiology
Brain Mapping
Cerebral Cortex - anatomy & histology
Cerebral Cortex - blood supply
Cerebral Cortex - physiology
Encoding
fMRI
Functional Laterality - physiology
Humans
Image Processing, Computer-Assisted - methods
Magnetic Resonance Imaging - methods
Male
Memory - physiology
Memory performance
Middle Aged
Oxygen - blood
Paired-Associate Learning - physiology
Parahippocampal gyrus
Regression Analysis
Retrieval
Verbal Learning - physiology
Retrieval
fMRI
Encoding
Memory performance
Parahippocampal gyrus
Online AccessGet full text

Cover

More Information
Summary:We studied the neural correlates for the performance of auditory verbal memory using fMRI in 28 normal right-handed volunteers who had to encode and retrieve 50 related word-pair associates. Since the effectiveness of encoding and retrieval processes contribute to memory performance, we combined them in one analysis in addition to examining each condition. Between-subjects analyses were performed by a two-sample t-test in which brain activation in the good-performance group was compared with that of the poor-performance group. Regression analysis was also carried out to find the regions whose activations were linearly correlated to the number of correct recalls by all subjects. In addition to the positive correlates of memory performance, the areas whose activations have a negative effect were also examined. The results indicate that the brain networks of positive correlates including the parahippocampal gyrus and negative correlates including the right prefrontal cortex constitute neural substrates for the performance of auditory verbal memory.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2004.04.018