The Role of Cathepsin B in Pathophysiologies of Non-tumor and Tumor tissues: A Systematic Review

• Published in: Journal of Cancer Vol. 14; no. 12; pp. 2344 - 2358
• Main Authors: Wang, Jiangping, Zheng, Minying, Yang, Xiaohui, Zhou, Xinyue, Zhang, Shiwu
• Format: Journal Article
• Language: English
• Published: Australia Ivyspring International Publisher 01.01.2023
• Subjects: Review; Cathepsin B; epithelial-mesenchymal transition; tumor microenvironment; cell death; extracellular matrix
• ISSN: 1837-9664; 1837-9664
• DOI: 10.7150/jca.86531

Cathepsin B (CTSB), a lysosomal cysteine protease, plays an important role in human physiology and pathology. CTSB is associated with various human diseases, and its expression level and activity are closely related to disease progression and severity. Physiologically, CTSB is integrated into almost all lysosome-related processes, including protein turnover, degradation, and lysosome-mediated cell death. CTSB can lead to the development of various pathological processes through degradation and remodeling of the extracellular matrix. During tumor development and progression, CTSB has two opposing effects. Its pro-apoptotic properties reduce malignancy, while its proteolytic enzymatic activity promotes invasion and metastasis, thereby inducing malignancy. Here, we discuss the roles of CTSB in tumor and non-tumor disease pathophysiologies. We conclude that targeting the activity or expression of CTSB may be important for treating tumor and non-tumor diseases.