The association of LOXL1 polymorphisms with exfoliation syndrome/glaucoma: Meta-analysis

• Published in: International journal of ophthalmology Vol. 8; no. 1; pp. 148 - 156
• Main Authors: Ji, Qing-Shan, Qi, Bing, Wen, Yue-Chun, Liu, Lian, Guo, Xiao-Ling, Yu, Guo-Cheng, Zhong, Jing-Xiang
• Format: Journal Article
• Language: English
• Published: China International Journal of Ophthalmology Press 18.02.2015; Press of International Journal of Ophthalmology (IJO PRESS)
• Subjects: exfoliation; exfoliation syndrome; glaucoma; Informatics Research; lysyl; lysyl oxidase-like 1; Meta-analysis; oxidase-like; polymorphism; syndrome; exfoliation syndrome; polymorphism; lysyl oxidase-like 1; glaucoma; Meta-analysis
• ISSN: 2222-3959; 2227-4898
• DOI: 10.3980/j.issn.2222-3959.2015.01.27

AIM: To investigate the association of lysyl oxidaselike 1(LOXL1) single nucleotide polymorphisms(SNPs)with exfoliation syndrome(XFS)/exfoliation glaucoma(XFG).METHODS: Published manuscripts from Pub Med and EMBASE were identified until May 2014. Summary odds ratios(ORs) and 95% confidence intervals(CIs) for LOXL1(rs1048661, rs2165241 and rs3825942) polymorphisms and the risk of XFS/XFG were estimated using random-or fixed- effect model.· RESULTS: The three LOXL1 polymorphisms(rs1048661, rs3825942, and rs2165241) were associated with an increased risk for XFS/XFG among Caucasians,with OR 2.19(1.96-2.45), 8.8(6.05-12.79) and 3.41(3.11-3.73), respectively. On the contrast, the rs1048661 and rs2165241, but not rs3825942 polymorphism, have a potential protective effect on XFS/XFG in Asians, with OR0.06(0.02-0.18), 0.15(0.09-0.25), respectively.CONCLUSION: There is strong evidence that LOXL1 polymorphisms are associated with XFS/XFG risk. The strength of risk might be ethnicity-dependent.