EARLY BREAKING STRENGTH OF REPAIRED FLEXOR TENDON TREATED WITH 5-FLUOROURACIL

This study investigated the effect of a single intraoperative application of 5-fluorouracil, which may diminish peritendinous adhesion formation, on the tensile strength of repaired digital flexor tendons after 7, 14 and 21 days of healing. Twenty-seven deep flexor tendons from 14 rabbits were expos...

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Bibliographic Details
Published inJournal of hand surgery, British volume Vol. 26; no. 3; pp. 220 - 223
Main Authors CEROVAC, S, AFOKE, A, AKALI, A, McGROUTHER, D.A
Format Journal Article
LanguageEnglish
Published London, England Elsevier Ltd 01.06.2001
SAGE Publications
Subjects
Animals
Fluorouracil - pharmacology
Male
Rabbits
Sutures
Tendon Injuries - physiopathology
Tendon Injuries - surgery
Tensile Strength
Tissue Adhesions - physiopathology
Wound Healing - drug effects
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Summary:This study investigated the effect of a single intraoperative application of 5-fluorouracil, which may diminish peritendinous adhesion formation, on the tensile strength of repaired digital flexor tendons after 7, 14 and 21 days of healing. Twenty-seven deep flexor tendons from 14 rabbits were exposed to 5-fluorouracil (50 mg/ml) for 5 minutes immediately after repair whereas matched control tendons were exposed to normal saline. Tensile testing at 7, 14 and 21 days revealed no significant differences in the gap or ultimate strengths of the 5-fluorouracil treated and control tendons.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0266-7681
1532-2211
DOI:10.1054/jhsb.2000.0537