MALDI mass spectrometric imaging meets "omics": recent advances in the fruitful marriage
Matrix-assisted laser desorption/ionization mass spectrometric imaging (MALDI MSI) is a method that allows the investigation of the molecular content of surfaces, in particular, tissues, within its morphological context. The applications of MALDI MSI in the field of large-scale mass spectrometric st...
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| Published in | Analyst (London) Vol. 14; no. 17; pp. 586 - 582 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
England
07.09.2015
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Matrix-assisted laser desorption/ionization mass spectrometric imaging (MALDI MSI) is a method that allows the investigation of the molecular content of surfaces, in particular, tissues, within its morphological context. The applications of MALDI MSI in the field of large-scale mass spectrometric studies, which are typically denoted by the suffix "omics", are steadily increasing. This is because, on the one hand, technical advances regarding sample collection and preparation, matrix application, instrumentation, and data processing have enhanced the molecular specificity and sensitivity of MALDI MSI; on the other hand, the focus of the "omics" community has moved from establishing an inventory of certain compound classes to exploring their spatial distribution to gain novel insights. Thus, the aim of this mini-review is twofold, to display the state-of-the-art in terms of technical aspects in MALDI MSI and to highlight selected applications in the last two years, which either have significantly advanced a certain "omics" field or have introduced a new one through pioneering efforts.
Matrix-assisted laser desorption/ionization mass spectrometric imaging (MALDI MSI) is a method that allows the investigation of the molecular content of surfaces, in particular, tissues, within its morphological context. |
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| Bibliography: | Ulrich S. Schubert studied chemistry in Frankfurt and Bayreuth and the Virginia Commonwealth University (USA). His Ph.D. studies were performed at the Universities of Bayreuth and Tampa (USA). After postdoctoral training with Jean-Marie Lehn at the University of Strasbourg (France), he moved to the TU München and obtained his Habilitation in 1999. From 1999 to 2000 he was Professor at the Center for NanoScience, University of Munich, and from 2000 to 2007 Full-Professor at TU Eindhoven (The Netherlands). Currently he holds a chair at the Friedrich Schiller University Jena with research interest in nanoparticle systems as sensor and drug delivery devices, supramolecular chemistry, inkjet printing of polymers, polymers for energy applications, and self-healing materials. Anna C. Crecelius obtained her Ph.D. in 2002 under the supervision of Prof. Malcolm R. Clench at the Sheffield Hallam University (UK). She has conducted post-doctoral research stays at universities including Vanderbilt University (USA) and Ludwig Maximillians University Munich. Currently, she is a senior research scientist in the group of Prof. Ulrich S. Schubert at the Friedrich Schiller University Jena. Her main research area is the development and application of mass spectrometric imaging techniques. Ferdinand von Eggeling studied Biology and Chemistry in Erlangen and finished his Ph.D. (1995) and his Habilitation (2003) at the Friedrich Schiller University Jena in Genetics. Since 2001 he was head of the Core Unit Chip Application (CUCA) at the Institute of Human Genetics. In 2009 he received the apl. Professor for Genetics at the Friedrich Schiller University Jena. Currently he has an affiliation at the Institute of Physical Chemistry and the ENT-Department of the University Hospital in Jena. His main interest is in mass spectrometric imaging of different tumour entities and the biological characterisation of functional tissue components. ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
| ISSN: | 0003-2654 1364-5528 |
| DOI: | 10.1039/c5an00990a |