Lack of change in blood pressure and arterial stiffness after high dairy intake in hyperinsulinemic subjects: a cross-over randomized controlled trial

• Published in: Applied physiology, nutrition, and metabolism Vol. 49; no. 3; pp. 350 - 359
• Main Authors: Arghavani, Hana, O'Connor, Sarah, Fortier, Catherine, Rudkowska, Iwona
• Format: Journal Article
• Language: English
• Published: Canada NRC Research Press 01.03.2024; Canadian Science Publishing NRC Research Press
• Subjects: Adult; Blood Pressure; Cardiovascular disease; Care and treatment; Clinical trials; Dairy products; Diabetes; Diagnosis; Endocrine disorders; Health aspects; Humans; Hypertension; Insulin; Low density lipoproteins; Pressure; Pulse Wave Analysis; Vascular Stiffness; Canada; arterial stiffness; arterial pressure; hyperinsulinemia; dairy products; augmentation index; carotid-femoral pulse wave velocity
• ISSN: 1715-5312; 1715-5320; 1715-5320
• DOI: 10.1139/apnm-2023-0053

To evaluate the effects of high dairy (HD) (≥4 servings/day), compared to adequate dairy (AD) (2–3 servings/day as per Canada's Food Guide for Healthy Eating (2007)), on blood pressure (BP) and measures of arterial stiffness in hyperinsulinemic subjects. In this cross-over clinical trial, hyperinsulinemic adults were randomized to AD and HD for 6 weeks. Anthropometric, glycemic, and lipid parameters were analyzed and dietary intake was evaluated; BP, carotid-femoral pulse wave velocity, augmentation index, and measures of arterial stiffness were assessed. Twenty-seven participants completed the study. Dairy intake was 2.2 ± 1.2 servings/day during AD. In addition, lower total and low-density lipoprotein (LDL) cholesterol were observed without significant change in BP or arterial stiffness between before and after AD. During HD, the subjects consumed 5.8 ± 1.9 servings/day of dairy products, providing a higher intake of protein, saturated fat, calcium, phosphorus, sodium, and potassium compared to the baseline diet. After the HD, subjects had higher body fat, fasting insulin, homeostatic model assessment for insulin resistance (HOMA-IR) index, and triglycerides without altering BP or arterial stiffness compared to before HD. Overall, adequate or high intake of total dairy did not modify BP or arterial stiffness in hyperinsulinemic adults after 6 weeks.