The Requirement for the Fc Portion of Antibody in Antigen-Antibody Complex-Mediated Suppression

The role of the Fc portion of antibody in immune complex-induced suppression was studied in vivo and in vitro. BSA pheasant anti-BSA complexes, formed in antigen excess (Ag1Ab1), were found to suppress both responses to BSA and SRBC. When complexes were formed with F(ab')2 fragments of pheasant...

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Published inThe Journal of immunology (1950) Vol. 120; no. 5; pp. 1669 - 1671
Main Authors Morgan, Edward L, Tempelis, Constantine H
Format Journal Article
LanguageEnglish
Published United States Am Assoc Immnol 01.05.1978
Subjects
Animals
Antibodies
Antigen-Antibody Complex
Birds
Chickens
Immunoglobulin Fc Fragments
Immunosuppression
Male
Serum Albumin, Bovine - immunology
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Summary:The role of the Fc portion of antibody in immune complex-induced suppression was studied in vivo and in vitro. BSA pheasant anti-BSA complexes, formed in antigen excess (Ag1Ab1), were found to suppress both responses to BSA and SRBC. When complexes were formed with F(ab')2 fragments of pheasant anti-BSA, no suppression was observed, indicating that the Fc piece was indeed essential for the induction of Ag-Ab complex-mediated suppression.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.120.5.1669