Two new dipimprinine alkaloids from soil-derived Streptomyces sp. 44414B

Two new dipimprinine alkaloids dipimprinine E ( 1 ) and dipimprinine F ( 2 ) were isolated from Streptomyces sp. 44414B. The structure was elucidated by extensive spectroscopic analysis, including ESI-MS, HR-MS, and 1D and 2D NMR experiments. Dipimprinines F ( 2 ) showed cytotoxic activities against...

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Published inJournal of antibiotics Vol. 74; no. 7; pp. 474 - 476
Main Authors Liu, Manli, Wan, Zhongyi, Yang, Sumei, Liu, Fang, Yang, Xiliang, Wu, Zhaoyuan, Zhang, Yanni, Wang, Kaimei, Fang, Wei
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.07.2021
Springer Nature
Nature Publishing Group
Subjects
631/154
631/92/349
Antibiotics
Bacteriology
Biomedical and Life Sciences
Bioorganic Chemistry
Biotechnology & Applied Microbiology
Brief Communication
Carbon
Chromatography
Cytotoxicity
Immunology
Life Sciences
Life Sciences & Biomedicine
Liver cancer
Lung cancer
Medicinal Chemistry
Microbiology
Organic Chemistry
Pharmacology & Pharmacy
Science & Technology
PIMPRININE
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Summary:Two new dipimprinine alkaloids dipimprinine E ( 1 ) and dipimprinine F ( 2 ) were isolated from Streptomyces sp. 44414B. The structure was elucidated by extensive spectroscopic analysis, including ESI-MS, HR-MS, and 1D and 2D NMR experiments. Dipimprinines F ( 2 ) showed cytotoxic activities against three tumor cell lines, including A-875, Hep G2, and H-460, with IC 50 values of 26.4, 0.5, and 9.0 μg ml −1 , respectively.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0021-8820
1881-1469
DOI:10.1038/s41429-021-00424-3