Coma and crystalluria: a massive primidone intoxication treated with haemoperfusion

The present paper describes a patient who was in danger of dying from a massive primidone overdose. She was comatose, hypotensive and in acute renal failure with crystalluria. Because of her clinical condition and high plasma primidone level (209 mg/l) haemoperfusion was instituted. Both the calcula...

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Bibliographic Details
Published inJournal of toxicology. Clinical toxicology Vol. 20; no. 4; p. 307
Main Authors van Heijst, A N, de Jong, W, Seldenrijk, R, van Dijk, A
Format Journal Article
LanguageEnglish
Published United States 1983
Subjects
Aged
Charcoal - therapeutic use
Coma - chemically induced
Coma - therapy
Female
Half-Life
Hemoperfusion
Humans
Kinetics
Phenobarbital - blood
Phenylethylmalonamide - blood
Primidone - metabolism
Primidone - poisoning
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Summary:The present paper describes a patient who was in danger of dying from a massive primidone overdose. She was comatose, hypotensive and in acute renal failure with crystalluria. Because of her clinical condition and high plasma primidone level (209 mg/l) haemoperfusion was instituted. Both the calculated drug clearances and the remarkable improvement in the patient's clinical condition suggest that haemoperfusion was very effective.
ISSN:0731-3810
DOI:10.3109/15563658308990598