Immunodetection of Tropheryma whipplei in Intestinal Tissues from Dr. Whipple's 1907 Patient

To the Editor: In 1907, George Whipple performed an autopsy on a 36-year-old patient and described unique findings characterizing the disease that now bears his name. “Foamy macrophages” in lymph nodes and the lamina propria of the small intestine are the hallmarks of Whipple's disease. In addi...

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Published inThe New England journal of medicine Vol. 348; no. 14; pp. 1411 - 1412
Main Authors Dumler, J. Stephen, Raoult, Didier, Baisden, Blaire L, Yardley, John H
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 03.04.2003
Subjects
History, 20th Century
Micrococcaceae - isolation & purification
Whipple Disease - history
Whipple Disease - microbiology
Whipple Disease - pathology
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Summary:To the Editor: In 1907, George Whipple performed an autopsy on a 36-year-old patient and described unique findings characterizing the disease that now bears his name. “Foamy macrophages” in lymph nodes and the lamina propria of the small intestine are the hallmarks of Whipple's disease. In addition, Whipple described a “number of rod-shaped organisms resembling in form the tubercle bacillus” in the vacuoles of the foamy cells. 1 The role of a bacterium in the disease was suggested but not yet acknowledged. By 1949, the contents of the foamy macrophages were shown to be positive on periodic acid–Schiff (PAS) staining, and . . .
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ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM200304033481425