Infection of inbred rat strains with Rift Valley fever virus: development of a congenic resistant strain and observations on age-dependence of resistance

A congenic rat strain (WF.LEW) was derived from the susceptible Wistar-Furth (WF) (background strain) and the resistant LEW (donor strain) inbred strains and was used to evaluate the phenotypic expression of a dominant Mendelian gene that confers resistance to fatal hepatic disease caused by the ZH5...

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Published inThe American journal of tropical medicine and hygiene Vol. 44; no. 5; p. 475
Main Authors Anderson, G.W. Jr. (United State Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD), Rosenbrock, J.A, Johnson, A.J, Jennings, G.B, Peters, C.J
Format Journal Article
LanguageEnglish
Published United States 01.05.1991
Subjects
AGE
Aging - immunology
Animals
EDAD
Encephalitis - genetics
Encephalitis - immunology
Encephalitis - microbiology
GENE
GENES
GENETICA
GENETIQUE
GENOTIPOS
GENOTYPE
Hepatitis, Viral, Animal - genetics
Hepatitis, Viral, Animal - immunology
Hepatitis, Viral, Animal - microbiology
Immunity, Innate - genetics
INFECCION
INFECTION
LIGNEE CONSANGUINE
LINEAS CONSANGUINEAS
RAT
RATA
Rats
Rats, Inbred Lew
Rats, Inbred WF
RESISTANCE AUX MALADIES
RESISTENCIA A LA ENFERMEDAD
Rift Valley Fever - genetics
Rift Valley Fever - immunology
Rift Valley Fever - microbiology
VIRUS FIEBRE DEL VALLE DEL RIFT
VIRUS FIEVRE DE LA VALLEE DU RIFT
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Summary:A congenic rat strain (WF.LEW) was derived from the susceptible Wistar-Furth (WF) (background strain) and the resistant LEW (donor strain) inbred strains and was used to evaluate the phenotypic expression of a dominant Mendelian gene that confers resistance to fatal hepatic disease caused by the ZH501 strain of Rift Valley fever virus (RVFV). Resistance to hepatic disease developed gradually with age, with full expression at approximately 10 weeks in the WF.LEW and LEW rat strains. The ZH501 strain caused fatal hepatitis in WF rats regardless of age. However, resistance to the SA75 RVFV strain (relatively non-pathogenic for adult rats), was age- and dose-dependent in both WF and LEW rats. The resistance gene transferred to the newly derived WF.LEW congenic rat strain appears to amplify age-dependent resistance of adult rats, resulting in protection against fatal hepatic disease caused by the virulent ZH501 strain. The congenic rat strain will be a valuable asset in elucidating the mechanism of resistance to Rift Valley fever virus governed by the dominant Mendelian gene
Bibliography:L73
T10
9183092
ISSN:0002-9637
1476-1645
DOI:10.4269/ajtmh.1991.44.475