Naphthoquinones from the roots of Aloe secundiflora
Two new naphthoquinones which include 5-hydroxy-3,6-dimethoxy-2-methylnaphthalene-1,4-dione (1) were isolated from the roots of Aloe secundiflora. Compound 1 and aloesaponarin I showed antibacterial activity against Mycobacterium tuberculosis. [Display omitted] ► Two new naphthoquinones were isolate...
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Published in | Phytochemistry letters Vol. 5; no. 3; pp. 506 - 509 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Elsevier Ltd
01.09.2012
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Subjects | |
Online Access | Get full text |
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Summary: | Two new naphthoquinones which include 5-hydroxy-3,6-dimethoxy-2-methylnaphthalene-1,4-dione (1) were isolated from the roots of Aloe secundiflora. Compound 1 and aloesaponarin I showed antibacterial activity against Mycobacterium tuberculosis. [Display omitted]
► Two new naphthoquinones were isolated from the roots of Aloe secundiflora. ► This is the first report on the occurrence of naphthoquinones in the genus Aloe. ► Antibacterial activity of selected metabolites against Mycobacterium tuberculosis is described.
Two new naphthoquinones, 5-hydroxy-3,6-dimethoxy-2-methylnaphthalene-1,4-dione and 5,8-dihydroxy-3-methoxy-2-methylnaphthalene-1,4-dione, were isolated from the roots of Aloe secundiflora together with the known compounds chrysophanol, helminthosporin, isoxanthorin, ancistroquinone C, aloesaponarins I and II, aloesaponols I and II, laccaic acid d methyl ester and asphodelin. The structures were elucidated based on spectroscopic evidence. This appears to be the first report on the occurrence of naphthoquinones in the genus Aloe. Aloesaponarin I and 5-hydroxy-3,6-dimethoxy-2-methylnaphthalene-1,4-dione showed anti-bacterial activity against Mycobacterium tuberculosis with MIC values of 21–23μg/mL in the Microplate Alamar Blue Assay (MABA) and Low Oxygen Recovery Assay (LORA); 5-hydroxy-3,6-dimethoxy-2-methylnaphthalene-1,4-dione also showed cytotoxicity against the Vero cell line (IC50=10.2μg/mL). |
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Bibliography: | http://dx.doi.org/10.1016/j.phytol.2012.04.014 |
ISSN: | 1874-3900 1876-7486 |
DOI: | 10.1016/j.phytol.2012.04.014 |