Naphthoquinones from the roots of Aloe secundiflora

Two new naphthoquinones which include 5-hydroxy-3,6-dimethoxy-2-methylnaphthalene-1,4-dione (1) were isolated from the roots of Aloe secundiflora. Compound 1 and aloesaponarin I showed antibacterial activity against Mycobacterium tuberculosis. [Display omitted] ► Two new naphthoquinones were isolate...

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Published inPhytochemistry letters Vol. 5; no. 3; pp. 506 - 509
Main Authors Induli, Martha, Cheloti, Michael, Wasuna, Antonina, Wekesa, Ingrid, Wanjohi, John M., Byamukama, Robert, Heydenrich, Matthias, Makayoto, Moses, Yenesew, Abiy
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.09.2012
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Summary:Two new naphthoquinones which include 5-hydroxy-3,6-dimethoxy-2-methylnaphthalene-1,4-dione (1) were isolated from the roots of Aloe secundiflora. Compound 1 and aloesaponarin I showed antibacterial activity against Mycobacterium tuberculosis. [Display omitted] ► Two new naphthoquinones were isolated from the roots of Aloe secundiflora. ► This is the first report on the occurrence of naphthoquinones in the genus Aloe. ► Antibacterial activity of selected metabolites against Mycobacterium tuberculosis is described. Two new naphthoquinones, 5-hydroxy-3,6-dimethoxy-2-methylnaphthalene-1,4-dione and 5,8-dihydroxy-3-methoxy-2-methylnaphthalene-1,4-dione, were isolated from the roots of Aloe secundiflora together with the known compounds chrysophanol, helminthosporin, isoxanthorin, ancistroquinone C, aloesaponarins I and II, aloesaponols I and II, laccaic acid d methyl ester and asphodelin. The structures were elucidated based on spectroscopic evidence. This appears to be the first report on the occurrence of naphthoquinones in the genus Aloe. Aloesaponarin I and 5-hydroxy-3,6-dimethoxy-2-methylnaphthalene-1,4-dione showed anti-bacterial activity against Mycobacterium tuberculosis with MIC values of 21–23μg/mL in the Microplate Alamar Blue Assay (MABA) and Low Oxygen Recovery Assay (LORA); 5-hydroxy-3,6-dimethoxy-2-methylnaphthalene-1,4-dione also showed cytotoxicity against the Vero cell line (IC50=10.2μg/mL).
Bibliography:http://dx.doi.org/10.1016/j.phytol.2012.04.014
ISSN:1874-3900
1876-7486
DOI:10.1016/j.phytol.2012.04.014