Melatonin in psychiatric disorders - subtyping affective disorder

Altered diurnal secretory patterns, i.e. altered phase and/or amplitude of melatonin have been reported in sleep and affective disorders. The alteration may depend on environmental factors which in vulnerable individuals may cause sleep and/or affective disorders. Early stress in conjunction with de...

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Bibliographic Details
Published inBiological signals and receptors Vol. 8; no. 1-2; p. 120
Main Author Wahlund, B
Format Journal Article
LanguageEnglish
Published Switzerland 01.01.1999
Subjects
Biomarkers - blood
Bipolar Disorder - blood
Bipolar Disorder - physiopathology
Humans
Hydrocortisone - blood
Melatonin - blood
Melatonin - physiology
Melatonin - secretion
Mental Disorders - blood
Mental Disorders - classification
Mental Disorders - physiopathology
Models, Neurological
Monoamine Oxidase - blood
Mood Disorders - blood
Mood Disorders - classification
Mood Disorders - physiopathology
Seasons
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Summary:Altered diurnal secretory patterns, i.e. altered phase and/or amplitude of melatonin have been reported in sleep and affective disorders. The alteration may depend on environmental factors which in vulnerable individuals may cause sleep and/or affective disorders. Early stress in conjunction with development of resistance to corticotropin-releasing hormone may be linked to the low melatonin syndrome in subgroups of depressed patients. Also the seasonal variation in melatonin as well as serotonin may be linked to the seasonal pattern seen in subgroups of affective disorders. Melatonin may be used as a combined marker for proneness to develop affective disorders especially in latent carriers of bipolar disorders.
ISSN:1422-4933
DOI:10.1159/000014579