Tri-Functional Calcium-Deficient Calcium Titanate Coating on Titanium Metal by Chemical and Heat Treatment

The main problem of orthopedic and dental titanium (Ti) implants has been poor bone-bonding to the metal. Various coatings to improve the bone-bonding, including the hydroxyapatite and titania, have been developed, and some of them have been to successfully applied clinical use. On the other hand, t...

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Bibliographic Details
Published inCoatings (Basel) Vol. 9; no. 9; p. 561
Main Authors Yamaguchi, Seiji, Thi Minh Le, Phuc, Ito, Morihiro, Shintani, Seine A., Takadama, Hiroaki
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 03.09.2019
Subjects
Apatite
Aqueous solutions
Biomedical materials
Body fluids
Calcium phosphates
Calcium titanate
Dental implants
E coli
Hydroxyapatite
Infections
Lasers
Metals
Orthopedics
Osteoporosis
Plasma
Reagents
Scanning electron microscopy
Solution heat treatment
Strontium
Surgical implants
Titanium
Titanium dioxide
Toxicity
Transplants & implants
Japan
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Summary:The main problem of orthopedic and dental titanium (Ti) implants has been poor bone-bonding to the metal. Various coatings to improve the bone-bonding, including the hydroxyapatite and titania, have been developed, and some of them have been to successfully applied clinical use. On the other hand, there are still challenges to provide antibacterial activity and promotion of bone growth on Ti. It was shown that a calcium-deficient calcium titanate coating on Ti and its alloys exhibits high bone-bonding owing to its apatite formation. In this study, Sr and Ag ions, known for their promotion of bone growth and antibacterial activity, were introduced into the calcium-deficient calcium titanate by a three-step aqueous solution treatment combined with heat. The treated metal formed apatite within 3 days in a simulated body fluid and exhibited antibacterial activity to Escherichia coli without showing any cytotoxicity in MC3T3-E1 preosteoblast cells. Furthermore, the metal slowly released 1.29 ppm of Sr ions. The Ti with calcium-deficient calcium titanate doped with Sr and Ag will be useful for orthopedic and dental implants, since it should bond to bone because of its apatite formation, promote bone growth due to Sr ion release, and prevent infection owing to its antibacterial activity.
ISSN:2079-6412
2079-6412
DOI:10.3390/coatings9090561