A case of Enterocytozoon bieneusi infection in an HIV-negative renal transplant recipient

Reported here is a case of microsporidiosis that occurred in an HIV-negative renal transplant recipient. The patient developed protracted diarrhea 18 months following transplant surgery. Many spores of Enterocytozoon bieneusi were detected in stool smears using a modified trichrome staining method....

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Published inEuropean journal of clinical microbiology & infectious diseases Vol. 19; no. 3; pp. 221 - 223
Main Authors METGE, S, TRAN VAN NHIEU, J, DAHMANE, D, GRIMBERT, P, FOULET, F, SARFATI, C, BRETAGNE, S
Format Journal Article
LanguageEnglish
Published Berlin Springer 01.03.2000
Springer Nature B.V
Subjects
Adult
AIDS/HIV
Animals
Biological and medical sciences
Diarrhea - parasitology
Enterocytozoon bieneusi
Feces - parasitology
Female
HIV Seronegativity
Human mycoses
Humans
Infectious diseases
Kidney Transplantation
Medical sciences
Microsporida - isolation & purification
Microsporidiosis - diagnosis
Microsporidiosis - parasitology
Mycoses
Mycoses of the digestive system
Human
Protozoa
Opportunistic infection
Protozoal disease
Diarrhea
Transplantation
Parasitosis
Homotransplantation
Kidney
Cnidosporidia
Infection
Case study
Pathology
Immunosuppression
Microbiological investigation
Mycological investigation
Surgery
Enterocytozoon bieneusi
Digestive diseases
Intestinal disease
Adult
Female
Microsporidiosis
Clinical investigation
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Summary:Reported here is a case of microsporidiosis that occurred in an HIV-negative renal transplant recipient. The patient developed protracted diarrhea 18 months following transplant surgery. Many spores of Enterocytozoon bieneusi were detected in stool smears using a modified trichrome staining method. Identification was confirmed using the polymerase chain reaction. Histological examination of duodenal biopsies revealed numerous spores in the cytoplasm of enterocytes. Tacrolimus and steroid regimens were decreased, treatment with mycophenolate mofetil was discontinued, and the patient was given albendazole and metronidazole for 2 weeks. The diarrhea resolved after 15 days of treatment; 2 months later the patient had recovered completely. A more systematic search for microsporidia using specific staining procedures should be performed in transplant recipients who develop severe diarrhea.
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ISSN:0934-9723
1435-4373
DOI:10.1007/s100960050463