A Practical Approach for Linearity Assessment of Calibration Curves Under the International Union of Pure and Applied Chemistry (IUPAC) Guidelines for an In-House Validation of Method of Analysis

Linearity assessment as required in method validation has always been subject to different interpretations and definitions by various guidelines and protocols. However, there are very limited applicable implementation procedures that can be followed by a laboratory chemist in assessing linearity. Th...

Full description

Saved in:
Bibliographic Details
Published inJournal of AOAC International Vol. 93; no. 4; pp. 1322 - 1330
Main Authors Sanagi, M Marsin, Nasir, Zalilah, Ling, Susie Lu, Hermawan, Dadan, Ibrahim, Wan Aini Wan, Naim, Ahmedy Abu
Format Journal Article
LanguageEnglish
Published England Oxford University Press 01.07.2010
Subjects
Calibration
Chemistry, Analytic
Chromatography, Gas - methods
Food Packaging
Guidelines as Topic
Methods
Plasticizers - analysis
Regression Analysis
Indonesia
Online AccessGet full text

Cover

More Information
Summary:Linearity assessment as required in method validation has always been subject to different interpretations and definitions by various guidelines and protocols. However, there are very limited applicable implementation procedures that can be followed by a laboratory chemist in assessing linearity. Thus, this work proposes a simple method for linearity assessment in method validation by a regression analysis that covers experimental design, estimation of the parameters, outlier treatment, and evaluation of the assumptions according to the International Union of Pure and Applied Chemistry guidelines. The suitability of this procedure was demonstrated by its application to an in-house validation for the determination of plasticizers in plastic food packaging by GC.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ObjectType-Undefined-3
ISSN:1060-3271
1944-7922
DOI:10.1093/jaoac/93.4.1322