Utilization of Intravenously Administered Glycogen by Young Pigs

• Published in: The Journal of nutrition Vol. 117; no. 2; pp. 274 - 279
• Main Authors: Andersen, Dean W., Stegink, Lewis D., Filer, L.J., Applebaum, A.E.
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Elsevier Inc 01.02.1987; American Society for Nutritional Sciences
• Subjects: ALIMENTACION; ALIMENTATION; Animals; AZUCARES; Biological and medical sciences; Blood Glucose - metabolism; Carbohydrates (enzymatic deficiencies). Glycogenosis; Carbohydrates - urine; CERDO; Errors of metabolism; FEEDING; GLICOGENO; GLYCOGEN; Glycogen - administration & dosage; Glycogen - metabolism; GLYCOGENE; Infusions, Intravenous; intravenous; Maltose - analogs & derivatives; Maltose - urine; Medical sciences; Metabolic diseases; METABOLISM; METABOLISME; METABOLISMO; oligosaccharide; Oligosaccharides - urine; PORCIN; SUCRES; SUGARS; SWINE; oligosaccharide; intravenous; glycogen; Vertebrata; Experimental disease; Mammalia; Intravenous administration; Glycogen; Metabolic diseases; Carbohydrate; Artiodactyla; Metabolism; Ungulata; Young animal; Pig
• ISSN: 0022-3166; 1541-6100
• DOI: 10.1093/jn/117.2.274

Previous studies evaluated solutions of small oligosaccharides as potential sources of carbohydrate-derived energy for patients fed intravenously. Although results with these solutions were disappointing, the data suggested that very large oligosaccharides were potential sources of intravenous carbohydrate. To test this hypothesis, four young pigs (3.6 ± 0.2 kg; mean ± SD) were infused with sterile solutions for a 6-d period. On days 1 and 6, a balanced isotonic electrolyte solution was infused. On days 2–5 a 9% solution of glycogen was infused at a rate providing 17.7 ± 0.77 g/d. For each study day the remaining portion of the energy, protein, essential fatty acids and micronutrients was supplied enterally. No adverse reactions were noted during glycogen infusion, and the animals continued to grow. Glycogen utilization was 66.4 ± 4.3%. Of the total carbohydrate excreted, 85.4% was composed of oligosaccharides of maltotetraose size or larger. Free glucose accounted for 3.5% of the total excreted, while maltose plus maltotriose accounted for 11.1%. Plasma concentrations of oligosaccharidebound glucose increased during glycogen infusion, rising from a base-line value of 11.0 ± 14 mg/dL to an overall mean value for the 4-d period of 100.3 ± 31.6 mg/dL.