Chinese quince (Chaenomeles sinensis) extract inhibits cell migration and cytokine release in HMC-1 cells

Chinese quince ( Chaenomeles sinensis ; CS) is known as a traditional oriental medicine for treating anaphylaxis and viral infection. Mast cells play an important role in a variety of inflammatory diseases. The inhibitory effects of CS extract on the inflammatory response of human mast cells were ex...

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Published inFood science and biotechnology Vol. 22; no. 2; pp. 501 - 506
Main Authors Kim, Do Hyung, Lee, Ji-Sook, Yun, Chi-Young, Kim, Dong-Hee, Kim, In Sik
Format Journal Article
LanguageEnglish
Published Heidelberg The Korean Society of Food Science and Technology 01.04.2013
한국식품과학회
Subjects
Anaphylaxis
Chemistry
Chemistry and Materials Science
Food Science
Nutrition
Research Article
Rosaceae
식품과학
mitogen-activated protein kinase
mast cell
)
anti-inflammatory effect
Chinese quince
Online AccessGet full text
ISSN1226-7708
2092-6456
DOI10.1007/s10068-013-0107-8

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Abstract Chinese quince ( Chaenomeles sinensis ; CS) is known as a traditional oriental medicine for treating anaphylaxis and viral infection. Mast cells play an important role in a variety of inflammatory diseases. The inhibitory effects of CS extract on the inflammatory response of human mast cells were examined. CS extract inhibited HMC-1 cell migration in response to stem cell factor (SCF). Its mechanism is involved in the inhibition of a surface expression of c-kit binding to SCF. Tumor necrosis factor (TNF)-α expression is induced by phorbol 12-myristate 13-acetate (PMA) and calcium ionophore (CaI). CS extract inhibited the TNF-α expression by blocking the activation of extracellular signal-regulated kinase (ERK), p38 mitogen-activated protein kinase (MAPK), and c-Jun-N-terminal kinase (JNK) in HMC-1 cells. CS extract suppressed the expression of interlukin (IL)-6, IL-8, and MCP-1 in human monocytic THP-1 cells, as well as the secretion of IL-6 in human keratinocytic HaCaT cells.
AbstractList Chinese quince (Chaenomeles sinensis; CS) is known as a traditional oriental medicine for treating anaphylaxis and viral infection. Mast cells play an important role in a variety of inflammatory diseases. The inhibitory effects of CS extract on the inflammatory response of human mast cells were examined. CS extract inhibited HMC-1 cell migration in response to stem cell factor (SCF). Its mechanism is involved in the inhibition of a surface expression of c-kit binding to SCF. Tumor necrosis factor (TNF)-? expression is induced by phorbol 12-myristate 13-acetate (PMA) and calcium ionophore (CaI). CS extract inhibited the TNF-? expression by blocking the activation of extracellular signal-regulated kinase (ERK), p38 mitogen-activated protein kinase (MAPK), and c-Jun-N-terminal kinase (JNK) in HMC-1 cells. CS extract suppressed the expression of interlukin (IL)-6, IL-8, and MCP-1 in human monocytic THP-1 cells, as well as the secretion of IL-6 in human keratinocytic HaCaT cells.
Chinese quince ( Chaenomeles sinensis ; CS) is known as a traditional oriental medicine for treating anaphylaxis and viral infection. Mast cells play an important role in a variety of inflammatory diseases. The inhibitory effects of CS extract on the inflammatory response of human mast cells were examined. CS extract inhibited HMC-1 cell migration in response to stem cell factor (SCF). Its mechanism is involved in the inhibition of a surface expression of c-kit binding to SCF. Tumor necrosis factor (TNF)-α expression is induced by phorbol 12-myristate 13-acetate (PMA) and calcium ionophore (CaI). CS extract inhibited the TNF-α expression by blocking the activation of extracellular signal-regulated kinase (ERK), p38 mitogen-activated protein kinase (MAPK), and c-Jun-N-terminal kinase (JNK) in HMC-1 cells. CS extract suppressed the expression of interlukin (IL)-6, IL-8, and MCP-1 in human monocytic THP-1 cells, as well as the secretion of IL-6 in human keratinocytic HaCaT cells.
Chinese quince (Chaenomeles sinensis; CS) is known as a traditional oriental medicine for treating anaphylaxis and viral infection. Mast cells play an important role in a variety of inflammatory diseases. The inhibitory effects of CS extract on the inflammatory response of human mast cells were examined. CS extract inhibited HMC-1 cell migration in response to stem cell factor (SCF). Its mechanism is involved in the inhibition of a surface expression of c-kit binding to SCF. Tumor necrosis factor (TNF)-α expression is induced by phorbol 12-myristate 13-acetate (PMA) and calcium ionophore (CaI). CS extract inhibited the TNF-α expression by blocking the activation of extracellular signal-regulated kinase (ERK), p38 mitogen-activated protein kinase (MAPK), and c-Jun-N-terminal kinase (JNK) in HMC-1cells. CS extract suppressed the expression of interlukin (IL)-6, IL-8, and MCP-1 in human monocytic THP-1 cells,as well as the secretion of IL-6 in human keratinocytic HaCaT cells. KCI Citation Count: 6
Author Kim, Do Hyung
Kim, In Sik
Lee, Ji-Sook
Kim, Dong-Hee
Yun, Chi-Young
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mast cell
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anti-inflammatory effect
Chinese quince
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Snippet Chinese quince ( Chaenomeles sinensis ; CS) is known as a traditional oriental medicine for treating anaphylaxis and viral infection. Mast cells play an...
Chinese quince (Chaenomeles sinensis; CS) is known as a traditional oriental medicine for treating anaphylaxis and viral infection. Mast cells play an...
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SubjectTerms Anaphylaxis
Chemistry
Chemistry and Materials Science
Food Science
Nutrition
Research Article
Rosaceae
식품과학
Title Chinese quince (Chaenomeles sinensis) extract inhibits cell migration and cytokine release in HMC-1 cells
URI https://link.springer.com/article/10.1007/s10068-013-0107-8
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Volume 22
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