Chinese quince (Chaenomeles sinensis) extract inhibits cell migration and cytokine release in HMC-1 cells

• Published in: Food science and biotechnology Vol. 22; no. 2; pp. 501 - 506
• Main Authors: Kim, Do Hyung, Lee, Ji-Sook, Yun, Chi-Young, Kim, Dong-Hee, Kim, In Sik
• Format: Journal Article
• Language: English
• Published: Heidelberg The Korean Society of Food Science and Technology 01.04.2013; 한국식품과학회
• Subjects: Anaphylaxis; Chemistry; Chemistry and Materials Science; Food Science; Nutrition; Research Article; Rosaceae; 식품과학; mitogen-activated protein kinase; mast cell; ); anti-inflammatory effect; Chinese quince
• ISSN: 1226-7708; 2092-6456
• DOI: 10.1007/s10068-013-0107-8

Chinese quince ( Chaenomeles sinensis ; CS) is known as a traditional oriental medicine for treating anaphylaxis and viral infection. Mast cells play an important role in a variety of inflammatory diseases. The inhibitory effects of CS extract on the inflammatory response of human mast cells were examined. CS extract inhibited HMC-1 cell migration in response to stem cell factor (SCF). Its mechanism is involved in the inhibition of a surface expression of c-kit binding to SCF. Tumor necrosis factor (TNF)-α expression is induced by phorbol 12-myristate 13-acetate (PMA) and calcium ionophore (CaI). CS extract inhibited the TNF-α expression by blocking the activation of extracellular signal-regulated kinase (ERK), p38 mitogen-activated protein kinase (MAPK), and c-Jun-N-terminal kinase (JNK) in HMC-1 cells. CS extract suppressed the expression of interlukin (IL)-6, IL-8, and MCP-1 in human monocytic THP-1 cells, as well as the secretion of IL-6 in human keratinocytic HaCaT cells.