The Trypanosoma cruzi -host-cell interplay: location, invasion, retention

Chagas disease is a debilitating human illness caused by infection with the protozoan Trypanosoma cruzi. A capacity to invade and replicate within many different cell types is a cornerstone of the remarkable fitness of this parasite. Although invasion occurs independently of actin polymerization, th...

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Published inNature reviews. Microbiology Vol. 3; no. 10; pp. 819 - 823
Main Authors Andrews, Norma W, Andrade, Luciana O
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.10.2005
Subjects
Animals
Chagas Disease - parasitology
Chagas Disease - physiopathology
Chagas' disease
Distribution
Fibroblasts - parasitology
Health aspects
Host-Parasite Interactions
Humans
Lysosomes - physiology
Movement
Phagocytes - parasitology
Risk factors
Trypanosoma cruzi
Trypanosoma cruzi - physiology
Brazil
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Summary:Chagas disease is a debilitating human illness caused by infection with the protozoan Trypanosoma cruzi. A capacity to invade and replicate within many different cell types is a cornerstone of the remarkable fitness of this parasite. Although invasion occurs independently of actin polymerization, the host cell still participates in the process, often in unexpected ways. Recent surprising findings indicate that host-cell lysosomes are indispensable, either by directly mediating invasion or by retaining these highly motile parasites inside cells.
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ISSN:1740-1526
1740-1534
DOI:10.1038/nrmicro1249