The Trypanosoma cruzi -host-cell interplay: location, invasion, retention
Chagas disease is a debilitating human illness caused by infection with the protozoan Trypanosoma cruzi. A capacity to invade and replicate within many different cell types is a cornerstone of the remarkable fitness of this parasite. Although invasion occurs independently of actin polymerization, th...
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Published in | Nature reviews. Microbiology Vol. 3; no. 10; pp. 819 - 823 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
England
Nature Publishing Group
01.10.2005
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Subjects | |
Online Access | Get full text |
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Summary: | Chagas disease is a debilitating human illness caused by infection with the protozoan Trypanosoma cruzi. A capacity to invade and replicate within many different cell types is a cornerstone of the remarkable fitness of this parasite. Although invasion occurs independently of actin polymerization, the host cell still participates in the process, often in unexpected ways. Recent surprising findings indicate that host-cell lysosomes are indispensable, either by directly mediating invasion or by retaining these highly motile parasites inside cells. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 1740-1526 1740-1534 |
DOI: | 10.1038/nrmicro1249 |