Vanillin Improves and Prevents Trinitrobenzene Sulfonic Acid-Induced Colitis in Mice

• Published in: The Journal of pharmacology and experimental therapeutics Vol. 330; no. 2; pp. 370 - 376
• Main Authors: Wu, Shih-Lu, Chen, Jaw-Chyun, Li, Chia-Cheng, Lo, Hsin-Yi, Ho, Tin-Yun, Hsiang, Chien-Yun
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2009; American Society for Pharmacology and Experimental Therapeutics
• Subjects: Animals; Benzaldehydes - therapeutic use; Colitis - chemically induced; Colitis - pathology; Colitis - prevention & control; Female; Mice; Mice, Inbred BALB C; Mice, Transgenic; Trinitrobenzenesulfonic Acid - toxicity

Inflammatory bowel disease (IBD) is chronic inflammatory and relapsing disease of the gut. It has been known that activation of nuclear factor-κB (NF-κB) and production of proinflammatory cytokines play important roles in the pathogenesis of IBD. In this study, the effect of vanillin (4-hydroxy-3-me...