Functional Activity of Sphingomyelin Cycle in Rat Liver in Chronic Toxic Hepatitis

• Published in: Bulletin of experimental biology and medicine Vol. 146; no. 6; pp. 726 - 729
• Main Authors: Serebrov, V. Yu, Kuzmenko, D. I, Burov, P. G, Novitsky, S. V
• Format: Journal Article
• Language: English
• Published: Boston Boston : Springer US 01.12.2008; Springer US; Springer Nature B.V
• Subjects: Animals; Biomedical and Life Sciences; Biomedicine; Biophysics and Biochemistry; Cell Biology; ceramidase; Ceramidases - metabolism; ceramide; Ceramides - metabolism; Chemical and Drug Induced Liver Injury - metabolism; Hepatitis, Chronic - metabolism; Internal Medicine; Laboratory Medicine; Liver - enzymology; Liver - metabolism; Liver - pathology; Lysophospholipids - metabolism; Male; Pathology; Rats; Sphingomyelin Phosphodiesterase - metabolism; sphingomyelinase; Sphingomyelins - metabolism; Sphingosine - analogs & derivatives; Sphingosine - metabolism; sphyngosine-1-phosphate; toxic hepatitis; sphingomyelinase; ceramide; ceramidase; sphyngosine-1-phosphate; toxic hepatitis
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-009-0387-4

Activities of sphingomyelinase and ceramidase decreased in the liver in chronic toxic hepatitis and the balance between the levels of proapoptotic ceramide and antiapoptotic sphyngosine-1-phosphate shifts towards the latter substance. Pronounced changes in the qualitative and quantitative composition of fatty acids in the sphingomyelin cycle effector molecules were revealed.