Serial proton magnetic resonance spectroscopy of ischemic brain injury in humans

Four patients were observed serially with 1H magnetic resonance spectroscopy (MRS) at times ranging from 3 days to 10 weeks after a documented ischemic event. Spectra were obtained from 8 cc volumes in infarcted regions and contralateral matched normal regions. Reproducible variations in n-acetyl as...

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Bibliographic Details
Published inInvestigative radiology Vol. 25; no. 9; p. 1034
Main Authors Fenstermacher, M J, Narayana, P A
Format Journal Article
LanguageEnglish
Published United States 01.09.1990
Subjects
Aged
Aspartic Acid - analogs & derivatives
Aspartic Acid - metabolism
Brain - metabolism
Cerebrovascular Disorders - diagnosis
Cerebrovascular Disorders - metabolism
Choline - metabolism
Creatine - metabolism
Female
Humans
Magnetic Resonance Spectroscopy
Male
Middle Aged
Phosphocreatine - metabolism
Time Factors
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Summary:Four patients were observed serially with 1H magnetic resonance spectroscopy (MRS) at times ranging from 3 days to 10 weeks after a documented ischemic event. Spectra were obtained from 8 cc volumes in infarcted regions and contralateral matched normal regions. Reproducible variations in n-acetyl aspartate (NAA), creatine + phosphocreatine (Cr + PCr), and the sequential changes in lactate and lipid resonances are related to the pathophysiology of stroke. A conspicuous lack of significant change in the choline (Cho) resonance with concomitant decrease in NAA and Cr + PCr is reported as a possible marker of ischemic injury.
ISSN:0020-9996
DOI:10.1097/00004424-199009000-00016