α-Melanocyte-Stimulating Hormone: Reduction in Adult Rat Brain After Monosodium Glutamate Treatment of Neonates

Intraperitoneal injection of monosodium glutamate in neonatal rats resulted in a 90 percent loss of α-melanocyte-stimulating hormone in hypothalamic and extrahypothalamic areas of the brain, whereas the amount of hormone in the pituitary gland did not change. The dramatic reduction of α-melanocyte-s...

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Bibliographic Details
Published inScience (American Association for the Advancement of Science) Vol. 205; no. 4408; pp. 827 - 829
Main Authors Eskay, R. L., Brownstein, M. J., Long, R. T.
Format Journal Article
LanguageEnglish
Published United States American Association for the Advancement of Science 24.08.1979
Subjects
Animals
Animals, Newborn
Arcuate nucleus
Brain
Brain - metabolism
Cerebral cortex
Endocrinology
Glutamates - pharmacology
Hormone research
Hormones
Hypothalamus
Intraperitoneal injections
Laboratory rats
Melanocyte-Stimulating Hormones - metabolism
Monosodium glutamate
Physiological aspects
Pituitary gland
Primary literature
Rats
Rats as laboratory animals
Sodium Glutamate - pharmacology
Somatotropin
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Summary:Intraperitoneal injection of monosodium glutamate in neonatal rats resulted in a 90 percent loss of α-melanocyte-stimulating hormone in hypothalamic and extrahypothalamic areas of the brain, whereas the amount of hormone in the pituitary gland did not change. The dramatic reduction of α-melanocyte-stimulating hormone in the brain suggests that its primary source there is the neuronal perikarya of the arcuate nucleus.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0036-8075
1095-9203
DOI:10.1126/science.462194