Pitfalls in fine-needle aspiration cytology diagnosis of ductal carcinoma in a lactating breast

Breast undergoes hormonal changes, especially during pregnancy and postpartum period and may be associated with benign and malignant lesions. These lesions can arise either de novo or can be an exacerbated change occurring in a preexisting breast lesion. The benign lesion in the lactating breast can...

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Published inInternational journal of applied and basic medical research Vol. 9; no. 2; pp. 107 - 110
Main Authors Mehdi, Hajra, Raju, Kalyani, Prasad, C, Shah, Manan
Format Journal Article
LanguageEnglish
Published India Wolters Kluwer India Pvt. Ltd 01.04.2019
Medknow Publications and Media Pvt. Ltd
Medknow Publications & Media Pvt. Ltd
Wolters Kluwer - Medknow
Subjects
Biopsy
Breast cancer
Breastfeeding & lactation
Carcinoma
Case Report
Cellular biology
Consent
Cytoplasm
English literature
Hormones
Lipids
Lymphatic system
Mammography
Progesterone
Prolactin
Sex hormones
Tumors
Ultrasonic imaging
lactating breast
fine-needle aspiration cytology of breast
Breast cancer
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Summary:Breast undergoes hormonal changes, especially during pregnancy and postpartum period and may be associated with benign and malignant lesions. These lesions can arise either de novo or can be an exacerbated change occurring in a preexisting breast lesion. The benign lesion in the lactating breast can show some degree of atypia due to the high levels of progesterone and prolactin which can mimic malignant features microscopically and can be overdiagnosed with breast cancer. On the other hand, breast cancer in the lactating breast can be underdiagnosed when the atypical cytological features are considered as hormonal changes. A few case reports are published in the literature regarding lactating adenoma undergoing malignant transformation. We present a case in 23 years postpartum lactating female with mass in bilateral breasts. Initially, the lesions were diagnosed with hormonal changes on cytology. On follow-up by fine-needle aspiration cytology and biopsy, it was diagnosed with infiltrating ductal carcinoma in both breasts. As far as our knowledge goes, this is the first-case report in the English literature of ductal carcinoma in the bilateral lactating breast arising de novo.
ISSN:2229-516X
2248-9606
DOI:10.4103/ijabmr.IJABMR_147_18