Erythroplasia of Queyrat. Treatment with topical 5‐fluorouracil

Seven adult men with biopsy‐confirmed erythroplasia of Queyrat (EQ) were cured of their disease with topically applied 5‐fluorouracil (5‐FU) under occlusion. Post‐treatment biopsy specimens revealed normal histologic findings and recurrence‐free follow‐up periods extended up to 70 months. It is sugg...

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Published inCancer Vol. 38; no. 4; pp. 1498 - 1502
Main Authors Goette, Ltc. Detlef K., Carson, Capt. Thomas E.
Format Journal Article
LanguageEnglish
Published New York Wiley Subscription Services, Inc., A Wiley Company 01.10.1976
Subjects
Administration, Topical
Adult
Aged
Carcinoma in Situ - drug therapy
Carcinoma, Squamous Cell - drug therapy
Erythroplasia - drug therapy
Fluorouracil - administration & dosage
Fluorouracil - therapeutic use
Humans
Male
Middle Aged
Penile Neoplasms - drug therapy
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Summary:Seven adult men with biopsy‐confirmed erythroplasia of Queyrat (EQ) were cured of their disease with topically applied 5‐fluorouracil (5‐FU) under occlusion. Post‐treatment biopsy specimens revealed normal histologic findings and recurrence‐free follow‐up periods extended up to 70 months. It is suggested that topical 5‐FU is the treatment of choice for histologically confirmed EQ because of its superior results compared with those of surgery or radiation therapy. Our view is corroborated by several single case reports of EQ similarly treated.
Bibliography:Chief, Dermatology Service, Naval Regional Medical Center, Oakland, CA 94627.
Assistant Chief, Dermatology Service, Letterman Army Medical Center.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(197610)38:4<1498::AID-CNCR2820380409>3.0.CO;2-#