inhibition of bacterial cell growth by ketone bodies

The effect of ketone bodies on the growth, in culture, of Escherichia coli was investigated. Both growth and glucose utilisation were inhibited in the presence of 20 mmol/l D-3-hydroxybutyrate. Lower concentrations of D-3-hydroxybutyrate caused proportionally less inhibition of growth. Acetoacetate...

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Bibliographic Details
Published inAustralian journal of experimental biology and medical science Vol. 59; no. Pt 5; pp. 639 - 649
Main Authors Potezny, N, Atkinson, E.R, Rofe, A.M, Conyers, R.A.J
Format Journal Article
LanguageEnglish
Published Australia 01.10.1981
Subjects
3-Hydroxybutyric Acid
Acetoacetates
Bacteria - drug effects
Bacteria - growth & development
Citrates - pharmacology
Citric Acid
Escherichia coli - drug effects
Escherichia coli - growth & development
Escherichia coli - metabolism
Glucose - metabolism
Hydroxybutyrates - pharmacology
Keto Acids - pharmacology
Ketone Bodies - pharmacology
malnutrition
starvation
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Summary:The effect of ketone bodies on the growth, in culture, of Escherichia coli was investigated. Both growth and glucose utilisation were inhibited in the presence of 20 mmol/l D-3-hydroxybutyrate. Lower concentrations of D-3-hydroxybutyrate caused proportionally less inhibition of growth. Acetoacetate also inhibited growth but other glycolytic inhibitors and chemical analogues of D-3-hydroxybutyrate either did not inhibit or proved to be too toxic for bacterial growth. Citrate enhanced the ketone body effect. D-3-hydroxybutyrate also inhibited the growth of Klebsiella pneumoniae, Enterobacter aerogenes, Citrobacter freundii and Salmonella typhimurium. The possible relationship between ketone body inhibition of cell growth and oxygen limitation is discussed.
ISSN:0004-945X
DOI:10.1038/icb.1981.57