National heart, lung, and blood institute state of the science symposium in therapeutic apheresis-Therapeutic apheresis in cardiovascular disease

• Published in: Journal of clinical apheresis Vol. 30; no. 3; pp. 183 - 187
• Main Authors: Winters, Jeffrey L., Cooper, Leslie T., Ratcliffe, Nora R., Wu, Yanyun, Moriarty, Patrick M.
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.06.2015; Wiley Subscription Services, Inc
• Subjects: Adsorption; Adult; Aged; apheresis; Apoptosis; Autoantibodies - chemistry; Blood Component Removal - methods; Cardiomyopathy, Dilated - therapy; Cardiovascular Diseases - therapy; Humans; Immune System; immunoadsorption; Immunosorbent Techniques; Inflammation; lipid apheresis; Middle Aged; myocarditis; National Heart, Lung, and Blood Institute (U.S.); peripheral vascular disease; Peripheral Vascular Diseases - therapy; Prevalence; Research Design; United States; United States; lipid apheresis; immunoadsorption; myocarditis; peripheral vascular disease; apheresis
• ISSN: 0733-2459; 1098-1101
• DOI: 10.1002/jca.21355

The National Heart, Lung, and Blood Institute in collaboration with the American Society for Apheresis, convened a State of the Science Symposium in November of 2012 due to the expanding application of therapeutic apheresis despite the lack of well‐designed research to address its efficacy. This article reviews the opportunities that were presented at this meeting in the area of cardiovascular disease (CVD), specifically the use of columns to adsorb autoantibodies in dilated cardiomyopathy or damaging lipids in peripheral vascular disease. Understanding how absorption of these pathologic substances alters the inflammatory response in these disorders is important for the application of these technologies to the treatment of CVD. J. Clin. Apheresis 30:183–187, 2015. © 2014 Wiley Periodicals, Inc.