COVID‐19 vaccination and treatment in vulnerable populations

Patients with cancer often have systemically repressed immune systems, due to a number of factors including potentially immunosuppressive treatment regimens as well as immune system-intrinsic effects. Given the importance of cellular immunity to SARS-CoV-2 in both protection and recovery from COVID-...

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Bibliographic Details
Published inImmunology Vol. 165; no. 2; pp. 141 - 142
Main Author Delgoffe, Greg M.
Format Journal Article Web Resource
LanguageEnglish
Published England Wiley Subscription Services, Inc 01.02.2022
John Wiley & Sons, Inc
Subjects
COVID-19
COVID-19 - epidemiology
COVID-19 - immunology
COVID-19 - prevention & control
COVID-19 vaccines
COVID-19 Vaccines - administration & dosage
COVID-19 Vaccines - immunology
Humans
SARS-CoV-2 - immunology
Vaccination
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Summary:Patients with cancer often have systemically repressed immune systems, due to a number of factors including potentially immunosuppressive treatment regimens as well as immune system-intrinsic effects. Given the importance of cellular immunity to SARS-CoV-2 in both protection and recovery from COVID-19, the use of off-the-shelf NK cells as a therapy to bolster antiviral cellular immunity could be of critical importance, as this virus can infect many different tissue types, especially in individuals with suppressed immune systems. 1. Whole blood-based measurement of SARS-CoV-2-specific T cells reveals asymptomatic infection and vaccine immunogenicity in healthy subjects and patients with solid-organ cancers.
Bibliography:SourceType-Other Sources-1
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ObjectType-Editorial-2
ObjectType-Commentary-1
ISSN:0019-2805
1365-2567
DOI:10.1111/imm.13445