Small‐molecule modulators of zymogen activation in the fibrinolytic and coagulation systems

The coagulation and fibrinolytic systems are central to the hemostatic mechanism, which works promptly on vascular injury and tissue damage. The rapid response is generated by specific molecular interactions between components in these systems. Thus, the regulation mechanism of the systems is progra...

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Published inThe FEBS journal Vol. 277; no. 18; pp. 3675 - 3687
Main Authors Hasumi, Keiji, Yamamichi, Shingo, Harada, Tomotaka
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.09.2010
Subjects
Animals
Biochemistry
Blood Coagulation
Blood Coagulation Factors - metabolism
Coagulation
conformation
Enzyme Activators - analysis
Enzyme Activators - chemistry
Enzyme Activators - metabolism
Enzyme Precursors - metabolism
Fibrinolysis
Fibrinolytic Agents - metabolism
Humans
Injuries
Molecular biology
plasma hyaluronan‐binding protein
plasminogen
plasminogen activator
protease
prothrombin
urokinase
zymogen activation
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Summary:The coagulation and fibrinolytic systems are central to the hemostatic mechanism, which works promptly on vascular injury and tissue damage. The rapid response is generated by specific molecular interactions between components in these systems. Thus, the regulation mechanism of the systems is programmed in each component, as exemplified by the elegant processes in zymogen activation. This review describes recently identified small molecules that modulate the activation of zymogens in the fibrinolytic and coagulation systems.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:1742-464X
1742-4658
DOI:10.1111/j.1742-4658.2010.07783.x