Role of epigenetic alterations in cholangiocarcinoma

Intrahepatic cholangiocarcinomas are rare malignant epithelial liver tumors arising from intrahepatic bile ducts. The prognosis of affected patients is poor. Several risk factors, including hepatolithiasis, liver fluke infection, and anatomical abnormalities associated with inflammation of the bilia...

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Published inJournal of Hepato‐Biliary‐Pancreatic Surgery Vol. 13; no. 4; pp. 274 - 279
Main Authors Tischoff, Iris, Wittekind, Christian, Tannapfel, Andrea
Format Journal Article
LanguageEnglish
Published Japan 01.07.2006
Subjects
Adenocarcinoma - genetics
Apoptosis - genetics
Bile Duct Neoplasms - genetics
Bile Ducts, Extrahepatic - pathology
Bile Ducts, Intrahepatic
Cell Adhesion - physiology
Cell Proliferation
Cell Transformation, Neoplastic - genetics
cholangiocarcinoma
Cholangiocarcinoma - genetics
CpG Islands - genetics
DNA Methylation
DNA Repair - physiology
Epigenesis, Genetic
Genes, Tumor Suppressor - physiology
Humans
tumor suppressor genes
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Summary:Intrahepatic cholangiocarcinomas are rare malignant epithelial liver tumors arising from intrahepatic bile ducts. The prognosis of affected patients is poor. Several risk factors, including hepatolithiasis, liver fluke infection, and anatomical abnormalities associated with inflammation of the biliary tract have been described. At present, little is known about the cellular and molecular mechanisms leading to the development of cholangiocarcinoma. In recent years, in addition to genetic alterations, epigenetic inactivation of (tumor suppressor) genes by promoter CpG island hypermethylation has been recognized as an important and alternative mechanism in tumorigenesis. This review discusses the epi‐genetic inactivation of different tumor suppressor genes in cholangiocarcinoma.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0944-1166
1868-6982
1436-0691
DOI:10.1007/s00534-005-1055-3